Gene: WNT16
Official Full Name: Wnt family member 16provided by HGNC
Gene Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11629 | WNT16 Knockout cell line (HCT 116) | Human | WNT16 | 1:2~1:4 | Negative | Online Inquiry |
KO11630 | WNT16 Knockout cell line (HEK293) | Human | WNT16 | 1:3~1:6 | Negative | Online Inquiry |
WNT16 Gene Knockout Cell Lines are specialized cellular models engineered to selectively disrupt the expression of the WNT16 gene, a crucial component in the Wnt signaling pathway, which plays a vital role in various biological processes such as cell proliferation, differentiation, and apoptosis. These cell lines are generated through advanced gene editing technologies, providing researchers with a powerful tool to study the functions and downstream effects of WNT16 in cellular environments.
The primary function of WNT16 Gene Knockout Cell Lines lies in their ability to facilitate the dissection of the molecular pathways influenced by WNT16. By abrogating WNT16 expression, researchers can investigate its role in disease mechanisms—particularly in cancer and bone development disorders—thereby clarifying its contributions to tumorigenesis or abnormal cell signaling. The knockout model effectively mimics the loss-of-function scenarios often seen in pathological conditions, enabling a deeper understanding of gene interactions and functional outcomes.
The scientific significance of these cell lines extends to both research and clinical applications. They can be utilized in high-throughput screening for potential drug candidates targeting Wnt pathway-related diseases, aiding in the development of precise therapeutic interventions. Additionally, the WNT16 knockout models serve as invaluable platforms for gene therapy exploration and regenerative medicine studies, where understanding the interplay of WNT signaling can inform treatment strategies.
What sets our WNT16 Gene Knockout Cell Lines apart from alternatives is their precise targeting and proven reliability. Each cell line undergoes rigorous validation, ensuring consistent phenotype and reproducibility across experimental settings. This reliability is crucial for researchers seeking accurate data in their investigations, providing confidence in their results and subsequent interpretations.
For researchers and clinicians dedicated to unlocking the intricacies of cellular signaling pathways, these knockout cell lines present a unique opportunity. Their application can lead to significant breakthroughs in understanding disease pathology and could pave the way for innovative therapeutic solutions. Our company leverages extensive expertise in genetic engineering and cellular biology, positioning us as a frontrunner in delivering high-quality biological products that empower scientific discovery and clinical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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