Gene: WFDC1
Official Full Name: WAP four-disulfide core domain 1provided by HGNC
Gene Summary: This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO12601 | WFDC1 Knockout cell line (HeLa) | Human | WFDC1 | 1:3~1:6 | Negative | Online Inquiry |
WFDC1 Gene Knockout Cell Lines are genetically engineered cellular models featuring a targeted disruption of the WFDC1 gene, known for its role in various biological processes, including immune response and cellular differentiation. These cell lines are invaluable tools in molecular biology allowing researchers to study the effects of the WFDC1 gene in a controlled environment, enabling a deeper understanding of its function and implications in health and disease.
The key mechanism of action of these knockout cell lines lies in the complete absence of the WFDC1 protein, allowing researchers to observe phenotypic changes and downstream effects stemming from the loss of this gene. Such investigations provide insights into the gene's role in critical pathways, including inflammation and tissue homeostasis, particularly relevant in the context of certain cancers and autoimmune disorders.
The scientific significance of WFDC1 Gene Knockout Cell Lines extends to their applications in both basic research and translational studies. Researchers can utilize these cell lines to conduct functional assays, drug screening, and gene expression analysis, thereby accelerating the discovery of novel therapeutic targets and understanding disease mechanisms. Furthermore, these knockout models facilitate the validation of WFDC1 as a potential biomarker, thus offering promise in clinical diagnostics.
Compared to other gene knockout systems, our WFDC1 Gene Knockout Cell Lines provide a streamlined approach with high specificity and reliability, minimizing off-target effects while maximizing reproducibility. This targeted gene disruption technology enhances experimental design flexibility and provides robust data that significantly informs research hypotheses.
For researchers and clinicians seeking to unravel complex biological questions or pursue innovative therapeutic strategies, WFDC1 Gene Knockout Cell Lines represent a crucial addition to the research toolkit. With our commitment to quality and excellence, our company stands at the forefront of providing advanced biological products that empower the scientific community, driving forward the frontiers of genetic research and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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