Gene: WDR73
Official Full Name: WD repeat domain 73provided by HGNC
Gene Summary: The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24433 | WDR73 Knockout cell line (HeLa) | Human | WDR73 | 1:3~1:6 | Negative | Online Inquiry |
KO24434 | WDR73 Knockout cell line (HCT 116) | Human | WDR73 | 1:2~1:4 | Negative | Online Inquiry |
KO24435 | WDR73 Knockout cell line (HEK293) | Human | WDR73 | 1:3~1:6 | Negative | Online Inquiry |
KO24436 | WDR73 Knockout cell line (A549) | Human | WDR73 | 1:3~1:4 | Negative | Online Inquiry |
WDR73 Gene Knockout Cell Lines represent a significant advancement in the field of molecular biology, specifically designed to facilitate the functional analysis of the WDR73 gene. This gene encodes a protein that plays a critical role in cellular pathways, including those involved in cellular differentiation and response to stress. The availability of knockout cell lines allows researchers to systematically investigate the biological functions of WDR73, offering insights into its role in various physiological and pathological contexts.
The key mechanism underlying WDR73 knockout cell lines involves the targeted disruption of the WDR73 gene, typically achieved through CRISPR-Cas9 technology. This method provides a precise and efficient means to create loss-of-function mutations that enable researchers to assess the phenotypic and molecular changes that result from the absence of this gene. By using these cell lines, scientists can delve into the implications of WDR73 deficiency on cellular behavior, signaling pathways, and disease models, which are paramount for understanding conditions such as cancer and neurodegenerative diseases.
The scientific importance of WDR73 Gene Knockout Cell Lines is multifaceted, serving not only as a pivotal tool in basic research but also holding potential applications in clinical settings. Their ability to elucidate gene function makes them instrumental in drug discovery and the development of novel therapeutic strategies. Additionally, they can provide a platform for screening compounds that might restore or compensate for the loss of WDR73 function, thus paving the way for innovative treatments.
One of the principal advantages of utilizing our WDR73 Gene Knockout Cell Lines is their validated performance and reproducibility, which are essential for rigorous scientific experimentation. Unlike alternative models that may utilize non-specific methods or lack proper characterization, our cell lines are developed with a clear focus on precision and reliability, ensuring the integrity of your experimental findings.
For researchers and clinicians seeking to advance their understanding of gene function and its implications in health and disease, the WDR73 Gene Knockout Cell Lines offer an invaluable resource. Our commitment to quality and innovation in biological products supports a wide array of research endeavors, reinforcing our position as a leading provider in the field.
Please note that all services are for research use only. Not intended for any clinical use.
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