Gene: WDR7
Official Full Name: WD repeat domain 7provided by HGNC
Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29432 | WDR7 Knockout cell line (HeLa) | Human | WDR7 | 1:3~1:6 | Negative | Online Inquiry |
KO29433 | WDR7 Knockout cell line (HCT 116) | Human | WDR7 | 1:2~1:4 | Negative | Online Inquiry |
KO29434 | WDR7 Knockout cell line (HEK293) | Human | WDR7 | 1:3~1:6 | Negative | Online Inquiry |
WDR7 Gene Knockout Cell Lines are genetically modified cell lines in which the WDR7 gene has been effectively disrupted, providing a unique model for studying the gene's functions and its implications in various biological processes. WDR7, or WD repeat domain 7, is implicated in cellular activities ranging from protein-protein interactions to participation in complex formation, influencing pathways relevant to cell proliferation, differentiation, and response to stress.
The primary function of these knockout cell lines is to elucidate the role of WDR7 by facilitating loss-of-function studies. By removing the gene's expression, researchers can observe the resultant phenotypic changes, which provides insights into its biological significance and potential interactions within cellular pathways. The knockout mechanism typically involves the use of CRISPR/Cas9 or similar gene-editing technologies, ensuring precise alterations that allow for high specificity in experimental outcomes.
In terms of scientific importance, WDR7 Gene Knockout Cell Lines hold substantial value in both research and clinical settings. Research applications include understanding diseases where WDR7's regulatory roles are significant, including certain cancers and metabolic disorders. In the clinical context, insights gained from these models can foster the development of therapeutic strategies targeting WDR7-related pathways, thus bridging the gap between basic research and clinical applications.
Compared to alternatives, our WDR7 Gene Knockout Cell Lines provide robust reproducibility, ease of use, and comprehensive characterizations that allow for a thorough understanding of gene function. Unlike transient knockdown methods, which may yield inconsistent results, the stable knockout ensures that researchers can conduct long-term studies with confidence in their experimental setup.
For researchers and clinicians, the value of WDR7 Gene Knockout Cell Lines lies in their ability to accelerate discovery and innovation in understanding complex biological processes and disorders. They represent a pivotal tool for elucidating the mechanistic underpinnings of gene-related diseases and validating therapeutic approaches.
At our company, we are committed to advancing scientific research through high-quality genetic models. Our expertise in developing precise and reliable gene knockout systems underlies our product offering, ensuring that our customers can have the resources necessary to pioneer their studies effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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