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WDPCP Knockout Cell Lines

Gene: WDPCP

Official Full Name: WD repeat containing planar cell polarity effectorprovided by HGNC

Gene Summary: This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23145 WDPCP Knockout cell line (HeLa) Human WDPCP 1:3~1:6 Negative Online Inquiry
KO23146 WDPCP Knockout cell line (HCT 116) Human WDPCP 1:2~1:4 Negative Online Inquiry
KO23147 WDPCP Knockout cell line (HEK293) Human WDPCP 1:3~1:6 Negative Online Inquiry
KO23148 WDPCP Knockout cell line (A549) Human WDPCP 1:3~1:4 Negative Online Inquiry

Background

WDPCP Gene Knockout Cell Lines are a revolutionary tool in cellular and molecular biology, specifically designed to study the functional role of the WD repeat-containing protein 42 (WDPCP) in various biological processes. These cell lines are engineered to lack the WDPCP gene, enabling researchers to investigate the implications of its absence on cellular function, signaling pathways, and interaction with other proteins.

These knockout cell lines operate through a targeted gene disruption mechanism, typically utilizing CRISPR-Cas9 technology or RNA interference methods. By precisely knocking out the WDPCP gene, researchers can differentiate between normal and aberrant cellular behaviors, facilitating deeper insights into the gene's influence on cellular development, motility, and disease progression. This mechanism is pivotal for elucidating the role of WDPCP in processes such as ciliogenesis, which is essential in various cell types.

The scientific importance of WDPCP Gene Knockout Cell Lines extends to both research and clinical applications. They serve as invaluable models for studying potential therapeutic interventions for diseases where the WDPCP pathway is implicated, including certain cancers and ciliopathy-related disorders. Their usage in drug screening and pathway analysis provides critical insights into disease mechanisms, assisting in the development of targeted therapies.

Compared to conventional models, these specialized cell lines offer a more precise approach to understanding gene function, drastically enhancing the specificity of experimental outcomes. Researchers benefit from the well-characterized nature of these lines, paired with robust support, ensuring reproducibility and reliability in experimental settings.

For researchers and clinicians aiming to push the boundaries of genetic research and therapeutic development, WDPCP Gene Knockout Cell Lines represent an essential asset that enables deeper exploration of complex biological systems. Our company is dedicated to providing high-quality, expertly validated biological products designed to empower scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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