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WASF3 Knockout Cell Lines

Gene: WASF3

Official Full Name: WASP family member 3provided by HGNC

Gene Summary: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03690 WASF3 Knockout cell line (HCT 116) Human WASF3 1:2~1:4 Negative Online Inquiry
KO03691 WASF3 Knockout cell line (HEK293) Human WASF3 1:3~1:6 Negative Online Inquiry

Background

WASF3 Gene Knockout Cell Lines are genetically modified cellular models specifically designed to investigate the function and regulation of the WASF3 gene, which is implicated in various cellular processes including actin dynamics, cell migration, and metastasis in cancer. By utilizing CRISPR-Cas9 technology, these cell lines exhibit a complete knockout of the WASF3 gene, allowing researchers to explore the consequences of its absence on cellular behavior and signaling pathways.

The primary function of these knockout cell lines is to provide a controlled environment for studying the role of WASF3 in cellular motility and morphogenesis. By examining these phenotypic changes, scientists can derive insights into the molecular mechanisms underlying various diseases, particularly cancer, where WASF3 has been shown to facilitate tumor invasion and metastasis. Furthermore, these cell lines enable the identification of potential therapeutic targets and the development of novel treatment strategies by revealing how manipulating WASF3 expression affects disease progression.

In research and clinical settings, WASF3 Gene Knockout Cell Lines hold significant scientific importance as they facilitate the validation of hypotheses regarding WASF3's role in disease models. This advanced model system permits more accurate simulations of in vivo conditions compared to traditional methods.

Unlike alternative models, these knockout cell lines are optimized for efficiency and reproducibility, ensuring that experiments yield reliable and interpretable results. They are also compatible with a wide range of assays, including migration, invasion, and drug response studies, which enhances their versatility for various research applications.

For researchers and clinicians focused on cancer biology, the ability to dissect the WASF3 gene function in a precise manner paves the way for innovative exploration into therapeutic interventions. By incorporating these cell lines into their research, they can accelerate the pace of discovery and move towards more effective, targeted therapies.

Our company is dedicated to advancing scientific research through a portfolio of high-quality genetic tools and models, and we leverage our expertise in genetic engineering to provide products like the WASF3 Gene Knockout Cell Lines, which empower investigators in their quests to unravel complex biological questions.

Please note that all services are for research use only. Not intended for any clinical use.

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