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UXS1 Knockout Cell Lines

Gene: UXS1

Official Full Name: UDP-glucuronate decarboxylase 1provided by HGNC

Gene Summary: This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06783 UXS1 Knockout cell line (HeLa) Human UXS1 1:3~1:6 Negative Online Inquiry
KO06784 UXS1 Knockout cell line (HCT 116) Human UXS1 1:2~1:4 Negative Online Inquiry
KO06785 UXS1 Knockout cell line (HEK293) Human UXS1 1:3~1:6 Negative Online Inquiry

Background

UXS1 Gene Knockout Cell Lines are specialized cellular models in which the UXS1 gene has been selectively disrupted or knocked out. The UXS1 gene encodes for the enzyme UDP-glucuronic acid decarboxylase, which plays a critical role in the biosynthesis of polysaccharides and glycosaminoglycans. By utilizing CRISPR-Cas9 technology or other gene-editing methodologies, these knockout cell lines enable researchers to effectively study the phenotypic consequences of UXS1 deficiency, providing valuable insights into metabolic pathways and cellular processes pertinent to various diseases.

The primary function of UXS1 Gene Knockout Cell Lines lies in their ability to mimic conditions relevant to human pathology, especially in areas related to glycan metabolism and its implications in cancer or developmental disorders. By understanding how the absence of UXS1 influences cellular behavior, researchers can unravel complex biological mechanisms, facilitating studies aimed at drug development or gene therapy strategies.

The scientific importance of these cell lines is underscored by their applications in both basic research and translational medicine. In research settings, they serve as vital tools for investigating gene function and regulatory networks, while their potential use in preclinical models can accelerate the validation of therapeutic targets.

What sets UXS1 Gene Knockout Cell Lines apart from traditional models is their precise genetic modification, resulting in reproducible and reliable data. Unlike general knockdown strategies that may yield variable results and off-target effects, knockout methodologies provide enhanced specificity, making these cell lines superior in the quest for accurate biological assessment.

For researchers and clinicians seeking innovative models to push the boundaries of knowledge in genomics and metabolic engineering, UXS1 Gene Knockout Cell Lines represent an invaluable resource. They not only enhance understanding of fundamental biological processes but also pave the way for novel therapeutic interventions.

Backed by our company's commitment to advancing scientific research through high-quality biological products, we are dedicated to providing researchers with unparalleled models and expertise that can accelerate discoveries and translate findings into impactful clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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