UCP3 Knockout Cell Lines

Gene: UCP3

Official Full Name: uncoupling protein 3provided by HGNC

Gene Summary: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO34855	UCP3 Knockout cell line (HeLa)	Human	UCP3	1:3~1:6	Negative	Online Inquiry
KO34856	UCP3 Knockout cell line (HCT 116)	Human	UCP3	1:2~1:4	Negative	Online Inquiry
KO34857	UCP3 Knockout cell line (A549)	Human	UCP3	1:3~1:4	Negative	Online Inquiry

Background

UCP3 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically disrupt the expression of the uncoupling protein 3 (UCP3) gene. UCP3 plays a critical role in regulating mitochondrial function and energy metabolism, making it a central focus in research related to obesity, diabetes, and other metabolic disorders. The construction of these knockout lines utilizes CRISPR-Cas9 technology, ensuring precise gene editing that allows for the study of UCP3's contribution to cellular processes and metabolic pathways.

The primary mechanism of action relies on the elimination of UCP3 protein expression, enabling researchers to investigate how its absence affects energy homeostasis, reactive oxygen species production, and fatty acid metabolism. These cell lines serve a variety of key functions in metabolic research, providing insight into the physiological and pathophysiological roles of UCP3 in skeletal muscle, adipose tissue, and other relevant tissues.

In scientific and clinical settings, UCP3 Gene Knockout Cell Lines offer invaluable tools for studying diseases linked to mitochondrial dysfunction and metabolic syndrome. They can assist in drug discovery, allowing for the identification of therapeutic targets and the evaluation of compounds that may restore normal metabolic function.

A significant advantage of using these knockout cell lines is their ability to model specific metabolic conditions more accurately than traditional models. They provide a controlled environment that eliminates confounding variables often present in whole organism studies, thereby yielding more reliable data and a clearer understanding of the gene's role.

For researchers, clinicians, and biotechnology companies focused on metabolic research and drug development, these cell lines represent a high-value resource that can accelerate scientific discovery. Our commitment to excellence in gene editing technologies and profound understanding of metabolic pathways ensures that our UCP3 Gene Knockout Cell Lines meet the highest standards, empowering researchers in their quest to uncover new therapies and advancements in the field of health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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