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UBQLN4 Knockout Cell Lines

Gene: UBQLN4

Official Full Name: ubiquilin 4provided by HGNC

Gene Summary: Enables K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Involved in DNA damage response; negative regulation of double-strand break repair via homologous recombination; and regulation of catabolic process. Located in several cellular components, including autophagosome; proteasome complex; and site of DNA damage. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00196 UBQLN4 gRNA5-gRNA6 KO plasmid UBQLN4 $850
KO00364 UBQLN4 Knockout cell line(Flp-In-TRex U2OS) Human UBQLN4 1:3~1:5 Negative Online Inquiry
KO00630 UBQLN4 Knockout cell line(HEK293) Human UBQLN4 1:3~1:6 Negative Online Inquiry
KO01931 UBQLN4 Knockout cell line (HeLa) Human UBQLN4 1:3~1:6 Negative Online Inquiry
KO01932 UBQLN4 Knockout cell line (HCT 116) Human UBQLN4 1:2~1:4 Negative Online Inquiry
KO01933 UBQLN4 Knockout cell line (A549) Human UBQLN4 1:3~1:4 Negative Online Inquiry

Background

UBQLN4 Gene Knockout Cell Lines are advanced cellular models engineered to silence the expression of the UBQLN4 gene, critical for understanding its role in various biological pathways and disease processes. These cell lines are generated using CRISPR-Cas9 technology, providing precise genomic editing capabilities that facilitate the study of gene function and regulation.

The primary function of the UBQLN4 knockout cell lines is to provide researchers with a valuable tool for investigating the consequences of UBQLN4 loss-of-function in cellular systems. This gene has been implicated in the regulation of protein homeostasis and its dysregulation is linked to neurodegenerative diseases and cancer. By studying these cell lines, scientists can elucidate the specific cellular mechanisms by which UBQLN4 influences protein degradation pathways and contributes to disease pathology.

The scientific importance of UBQLN4 knockout cell lines is underscored by their application in various fields of research, including cancer biology, neurobiology, and drug discovery. They offer a platform for researchers to identify novel therapeutic targets and evaluate the efficacy of potential drug candidates. Furthermore, these cell lines can facilitate high-throughput screening for compounds that modulate UBQLN4 activity, thus accelerating the pace of translational research.

Compared to traditional cell lines, the UBQLN4 knockout models provide a high degree of specificity and control over gene expression, minimizing off-target effects that can confound experimental results. This specificity enhances the reliability of the data generated, making them a preferred choice among researchers seeking to understand genetic functions in a more nuanced way.

For researchers and clinicians, the UBQLN4 Gene Knockout Cell Lines represent an invaluable asset, enabling rigorous exploration of gene functions and contributing to significant scientific advancements. Our company prides itself on being at the forefront of genomic innovation, providing high-quality biological products that empower scientific discovery and enhance research capabilities.

Please note that all services are for research use only. Not intended for any clinical use.

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