Gene: TTC3
Official Full Name: tetratricopeptide repeat domain 3provided by HGNC
Gene Summary: Enables ubiquitin-protein transferase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05556 | TTC3 Knockout cell line (HeLa) | Human | TTC3 | 1:3~1:6 | Negative | Online Inquiry |
KO05557 | TTC3 Knockout cell line (HCT 116) | Human | TTC3 | 1:2~1:4 | Negative | Online Inquiry |
KO05558 | TTC3 Knockout cell line (HEK293) | Human | TTC3 | 1:3~1:6 | Negative | Online Inquiry |
KO05559 | TTC3 Knockout cell line (A549) | Human | TTC3 | 1:3~1:4 | Negative | Online Inquiry |
TTC3 Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the TTC3 gene, a crucial determinant in various biological processes, including protein degradation and regulation of cellular stress responses. These knockout cell lines utilize a targeted genetic modification approach, typically employing CRISPR-Cas9 or similar gene-editing technologies, to disrupt the TTC3 gene’s function, thereby allowing researchers to study the resultant phenotypic changes in cellular function, gene expression, and metabolic pathways.
The primary mechanism of action in TTC3 knockout cell lines involves the silencing of gene expression, leading to altered proteostasis and increased sensitivity to stressors. Without the TTC3 protein, cells may exhibit changes in autophagy, apoptosis, and cellular signaling pathways, making these models vital for understanding the gene's role in health and disease contexts, including cancer research and neurodegenerative disorders.
In research and clinical settings, TTC3 Gene Knockout Cell Lines facilitate significant advancements in the exploration of gene function, drug development, and pathophysiological investigations. By enabling high-throughput screening and functional assays, these cell lines provide a robust platform for dissecting cellular mechanisms and validating therapeutic targets.
Unique advantages of our TTC3 Gene Knockout Cell Lines include their high specificity and reproducibility, ensuring consistent outcomes across experiments. They offer a time-efficient alternative to traditional knockout models, such as transgenic or knockdown approaches, as they provide a complete gene knockout without off-target effects associated with RNA interference methods. This precision significantly enhances the reliability of experimental data.
The value of TTC3 Gene Knockout Cell Lines cannot be overstated, as they empower researchers and clinicians to delve deeper into gene function and its implications in disease. Their application can lead to breakthroughs in therapeutic strategies, ultimately contributing to improved patient outcomes.
With a rigorous commitment to quality and a depth of expertise in genetic engineering, our company provides superior biological products, including the TTC3 Gene Knockout Cell Lines, to support cutting-edge research and clinical discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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