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TRIP11 Knockout Cell Lines

Gene: TRIP11

Official Full Name: thyroid hormone receptor interactor 11provided by HGNC

Gene Summary: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33343 TRIP11 Knockout cell line (HeLa) Human TRIP11 1:3~1:6 Negative Online Inquiry
KO33344 TRIP11 Knockout cell line (HCT 116) Human TRIP11 1:2~1:4 Negative Online Inquiry
KO33345 TRIP11 Knockout cell line (HEK293) Human TRIP11 1:3~1:6 Negative Online Inquiry
KO33346 TRIP11 Knockout cell line (A549) Human TRIP11 1:3~1:4 Negative Online Inquiry

Background

TRIP11 Gene Knockout Cell Lines are engineered cellular models designed to facilitate the comprehensive study of the TRIP11 gene's function within a variety of biological contexts. The TRIP11 (Thyroid Hormone Receptor Interacting Protein 11) gene is implicated in crucial cellular processes such as endoplasmic reticulum function, protein trafficking, and maintaining cellular homeostasis. By knocking out this specific gene, researchers can directly evaluate the impact on cell behavior, signaling pathways, and disease models, thereby unraveling its physiological significance.

The key mechanisms at play involve CRISPR-Cas9 gene-editing technology, which allows for precise deletion of the TRIP11 gene in the cell lines. This results in a significant alteration in cellular functions, making it an invaluable tool for scientists investigating the gene's role in various conditions, such as developmental disorders or metabolic diseases. With these knockout models, researchers can delve into the molecular interactions and biological networks that rely on TRIP11, thereby contributing to a deeper understanding of cellular biology.

In clinical and research environments, TRIP11 Gene Knockout Cell Lines offer a significant advance over traditional models, such as wild-type cell lines or models using less precise gene-editing techniques. Their specificity and reliability provide reproducibility in experiments, allowing for enhanced result validation. Moreover, these cell lines can be readily used in high-throughput screening and drug discovery efforts, opening avenues for targeted therapeutic interventions.

For researchers and clinicians engaged in molecular biology, genetics, or pharmacology, the availability of TRIP11 Gene Knockout Cell Lines represents an essential asset for exploring complex biological systems and developing innovative therapeutic strategies. With their precise gene-editing capabilities and the potential to mimic pathological conditions, these models ensure impactful research outcomes.

Our company prides itself on leading the way in high-quality biological products and cutting-edge gene-editing technologies. By providing TRIP11 Gene Knockout Cell Lines, we are committed to facilitating advanced research that drives scientific discovery and healthcare innovations.

Please note that all services are for research use only. Not intended for any clinical use.

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