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TRIM59 Knockout Cell Lines

Gene: TRIM59

Official Full Name: tripartite motif containing 59provided by HGNC

Gene Summary: Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13055 TRIM59 Knockout cell line (HeLa) Human TRIM59 1:3~1:6 Negative Online Inquiry
KO13056 TRIM59 Knockout cell line (HCT 116) Human TRIM59 1:2~1:4 Negative Online Inquiry
KO13057 TRIM59 Knockout cell line (HEK293) Human TRIM59 1:3~1:6 Negative Online Inquiry
KO13058 TRIM59 Knockout cell line (A549) Human TRIM59 1:3~1:4 Negative Online Inquiry

Background

TRIM59 Gene Knockout Cell Lines are specifically engineered cellular models that lack the expression of the TRIM59 gene, a member of the Tripartite Motif (TRIM) family known to play a critical role in various biological processes, including immune response, apoptosis, and cellular proliferation. The knockout strategy employed ensures the complete deletion of the TRIM59 coding sequence, thereby enabling researchers to study the gene's functional implications without the confounding effects of its normal expression.

These cell lines function as a powerful tool for in-depth investigation of TRIM59's role in pathophysiological conditions such as cancer, neurodegenerative disorders, and autoimmune diseases. By providing a system to observe the phenotypic and molecular changes upon TRIM59 depletion, researchers can elucidate its contribution to disease mechanisms and potential therapeutic avenues. Furthermore, these cell lines can be utilized for drug screening, targeting TRIM59-related pathways, or understanding gene interactions within cellular networks.

One significant advantage of using TRIM59 Gene Knockout Cell Lines is their precision in genetic modification, allowing for reproducibility and reliability that surpasses traditional knockout methods. Unlike transient knockdowns, these stable cell lines maintain the knockout phenotype over extended periods, providing a consistent platform for long-term studies. Additionally, they serve as ideal controls in experiments designed to evaluate the effects of TRIM59 on various stimuli or treatments.

For researchers and clinicians, the TRIM59 Gene Knockout Cell Lines represent an invaluable resource, enabling rigorous exploration of gene function and offering insights that could translate into innovative therapeutic strategies. Supported by our company's robust background in genetic engineering and cellular biology, we are committed to providing high-quality biological products that meet the diverse needs of researchers worldwide.

Please note that all services are for research use only. Not intended for any clinical use.

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