Gene: TRIM33
Official Full Name: tripartite motif containing 33provided by HGNC
Gene Summary: The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22387 | TRIM33 Knockout cell line (HeLa) | Human | TRIM33 | 1:3~1:6 | Negative | Online Inquiry |
KO22388 | TRIM33 Knockout cell line (HCT 116) | Human | TRIM33 | 1:2~1:4 | Negative | Online Inquiry |
KO22389 | TRIM33 Knockout cell line (HEK293) | Human | TRIM33 | 1:3~1:6 | Negative | Online Inquiry |
KO22390 | TRIM33 Knockout cell line (A549) | Human | TRIM33 | 1:3~1:4 | Negative | Online Inquiry |
TRIM33 Gene Knockout Cell Lines are genetically modified cell lines in which the TRIM33 gene, known for its role in regulating various cellular processes including transcription, cell differentiation, and immune responses, has been functionally disrupted. By utilizing CRISPR/Cas9 technology, these knockout models allow for precise alteration of the TRIM33 gene, thereby providing a robust platform for understanding the gene's function in pathophysiological contexts such as cancer and autoimmune disorders.
The primary function of TRIM33 knockout cell lines centers around the study of gene regulation pathways and the implications of TRIM33 in various biological processes. These cell lines exhibit altered signal transduction mechanisms, providing insights into how the absence of TRIM33 influences cellular responses to stimuli, such as cytokine signaling and cell proliferation. Researchers can effectively utilize these models to delineate the cellular and molecular mechanisms in which TRIM33 is involved, thereby enhancing the understanding of its role in health and disease.
The scientific importance of TRIM33 Gene Knockout Cell Lines extends beyond basic research; they are invaluable in translational studies and drug development. By elucidating the role of TRIM33 in tumorigenesis or autoimmune conditions, these cell lines can assist in identifying potential therapeutic targets and biomarkers, leading to advancements in clinical strategies. In comparison to conventional cell lines, the distinct advantage of utilizing TRIM33 knockout variants lies in their capability to provide more accurate models that mirror the specific genetic disruptions found in human diseases, ultimately improving experimental reproducibility and relevance.
For researchers and clinicians, the value of TRIM33 Gene Knockout Cell Lines cannot be overstated. They empower the investigation into previously opaque biological pathways and facilitate the development of novel interventions. With a commitment to excellence and innovation in biological products, our company is positioned as a leader in providing high-quality genomic tools that enhance the understanding of gene function in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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