Gene: TPM4
Official Full Name: tropomyosin 4provided by HGNC
Gene Summary: This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04501 | TPM4 Knockout cell line (HeLa) | Human | TPM4 | 1:3~1:6 | Negative | Online Inquiry |
KO04502 | TPM4 Knockout cell line (HCT 116) | Human | TPM4 | 1:2~1:4 | Negative | Online Inquiry |
KO04503 | TPM4 Knockout cell line (HEK293) | Human | TPM4 | 1:3~1:6 | Negative | Online Inquiry |
KO04504 | TPM4 Knockout cell line (A549) | Human | TPM4 | 1:3~1:4 | Negative | Online Inquiry |
TPM4 Gene Knockout Cell Lines are engineered cellular models specifically designed to disrupt the expression of the tropomyosin 4 (TPM4) gene. This precise genetic alteration allows researchers to investigate the functional consequences of TPM4 depletion in a variety of biological contexts, particularly related to cytoskeletal dynamics and cellular motility. TPM4 plays a crucial role in regulating actin filament stability and organization, which are essential processes in cell shape maintenance, division, and intracellular transport.
The mechanisms through which TPM4 influences cellular behavior include modulation of actin polymerization and interaction with various actin-binding proteins. By utilizing CRISPR/Cas9 technology, our TPM4 gene knockout cell lines ensure high specificity and efficiency in gene disruption, providing researchers with a robust tool to study the role of TPM4 in cancer progression, neuromuscular diseases, and other pathologies where cytoskeletal dysfunction is implicated.
The scientific importance of these cell lines cannot be overstated; they have broad applications in basic research, drug discovery, and therapeutic development. Researchers can leverage these models to explore novel therapeutic targets or to test the efficacy of compounds aimed at modulating the cytoskeletal framework.
What sets our TPM4 gene knockout cell lines apart from alternative products is not only their superior accuracy in gene editing but also their optimized growth conditions that enable reproducible and reliable experimental outcomes. This quality ensures that researchers can draw meaningful conclusions from their studies, thereby enhancing the reliability of their work.
For laboratories seeking to deepen their understanding of cytoskeletal biology or develop innovative strategies for disease intervention, the TPM4 Gene Knockout Cell Lines represent an invaluable asset. Our company is dedicated to providing cutting-edge biological products backed by rigorous scientific research, making us a trusted partner in advancing your research goals.
Please note that all services are for research use only. Not intended for any clinical use.
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