Gene: TOPORS
Official Full Name: TOP1 binding arginine/serine rich protein, E3 ubiquitin ligaseprovided by HGNC
Gene Summary: This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32148 | TOPORS Knockout cell line (HeLa) | Human | TOPORS | 1:3~1:6 | Negative | Online Inquiry |
KO32149 | TOPORS Knockout cell line (HCT 116) | Human | TOPORS | 1:2~1:4 | Negative | Online Inquiry |
KO32150 | TOPORS Knockout cell line (HEK293) | Human | TOPORS | 1:3~1:6 | Negative | Online Inquiry |
KO32151 | TOPORS Knockout cell line (A549) | Human | TOPORS | 1:3~1:4 | Negative | Online Inquiry |
TOPORS Gene Knockout Cell Lines are advanced biological tools designed to facilitate the study of gene function through the methodical inactivation of the TOPORS gene. Utilizing CRISPR/Cas9 technology, these cell lines exhibit a complete knockout of TOPORS, a gene known to play critical roles in DNA repair, transcriptional regulation, and tumorigenesis. The directed disruption of this gene allows researchers to gain insights into its functional pathways, elucidating its various biological roles under both physiological and pathological conditions.
The TOPORS gene is implicated in a range of cellular processes, including the modulation of stress responses and regulation of cell cycle, making it a subject of intense study in cancer research and therapeutic development. The knockout cell lines maintain high fidelity for essential cellular characteristics while providing an efficient platform for functional assays, including gene expression analysis, drug response studies, and mechanistic investigations into TOPORS-related pathways.
One of the primary advantages of using TOPORS Gene Knockout Cell Lines is their specificity and reliability compared to traditional knockout methods, which often introduce off-target effects. Furthermore, researchers benefit from the availability of validated knockout clones that significantly reduce experimental variability. The ease with which these cell lines can be manipulated for downstream applications provides an additional incentive for their use in both research and clinical settings.
Researchers and clinicians who seek to understand the intricate workings of the TOPORS gene will find exceptional value in these knockout cell lines. They represent critical resources for advancing knowledge in gene function, disease modeling, and potential therapeutic strategies. As leaders in the biological products field, our company is committed to delivering high-quality, rigorously validated products that propel research innovation and biomedical advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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