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TOPORS Knockout Cell Lines

Gene: TOPORS

Official Full Name: TOP1 binding arginine/serine rich protein, E3 ubiquitin ligaseprovided by HGNC

Gene Summary: This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32148 TOPORS Knockout cell line (HeLa) Human TOPORS 1:3~1:6 Negative Online Inquiry
KO32149 TOPORS Knockout cell line (HCT 116) Human TOPORS 1:2~1:4 Negative Online Inquiry
KO32150 TOPORS Knockout cell line (HEK293) Human TOPORS 1:3~1:6 Negative Online Inquiry
KO32151 TOPORS Knockout cell line (A549) Human TOPORS 1:3~1:4 Negative Online Inquiry

Background

TOPORS Gene Knockout Cell Lines are advanced biological tools designed to facilitate the study of gene function through the methodical inactivation of the TOPORS gene. Utilizing CRISPR/Cas9 technology, these cell lines exhibit a complete knockout of TOPORS, a gene known to play critical roles in DNA repair, transcriptional regulation, and tumorigenesis. The directed disruption of this gene allows researchers to gain insights into its functional pathways, elucidating its various biological roles under both physiological and pathological conditions.

The TOPORS gene is implicated in a range of cellular processes, including the modulation of stress responses and regulation of cell cycle, making it a subject of intense study in cancer research and therapeutic development. The knockout cell lines maintain high fidelity for essential cellular characteristics while providing an efficient platform for functional assays, including gene expression analysis, drug response studies, and mechanistic investigations into TOPORS-related pathways.

One of the primary advantages of using TOPORS Gene Knockout Cell Lines is their specificity and reliability compared to traditional knockout methods, which often introduce off-target effects. Furthermore, researchers benefit from the availability of validated knockout clones that significantly reduce experimental variability. The ease with which these cell lines can be manipulated for downstream applications provides an additional incentive for their use in both research and clinical settings.

Researchers and clinicians who seek to understand the intricate workings of the TOPORS gene will find exceptional value in these knockout cell lines. They represent critical resources for advancing knowledge in gene function, disease modeling, and potential therapeutic strategies. As leaders in the biological products field, our company is committed to delivering high-quality, rigorously validated products that propel research innovation and biomedical advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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