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TOM1 Knockout Cell Lines

Gene: TOM1

Official Full Name: target of myb1 membrane trafficking proteinprovided by HGNC

Gene Summary: This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32353 TOM1 Knockout cell line (HeLa) Human TOM1 1:3~1:6 Negative Online Inquiry
KO32354 TOM1 Knockout cell line (HCT 116) Human TOM1 1:2~1:4 Negative Online Inquiry
KO32355 TOM1 Knockout cell line (HEK293) Human TOM1 1:3~1:6 Negative Online Inquiry
KO32356 TOM1 Knockout cell line (A549) Human TOM1 1:3~1:4 Negative Online Inquiry

Background

TOM1 Gene Knockout Cell Lines are genetically engineered cell lines designed to lack the TOM1 gene, which encodes a protein involved in intracellular trafficking and endosomal sorting. By specifically knocking out the TOM1 gene, these cell lines serve as invaluable tools for investigating the molecular pathways that regulate cellular functions such as endocytosis, cytosolic protein degradation, and immune response modulation.

The primary mechanism by which TOM1-knockout cells operate involves the disruption of protein interactions linked to the endosomal sorting complex required for transport (ESCRT) pathway, leading to alterations in protein stability and cellular signaling processes. Researchers can utilize these cell lines to study the role of TOM1 in various biological contexts, including its implications in cancer biology, neurodegenerative diseases, and immune responses. The ability to dissect these complex pathways presents significant opportunities for advancing our understanding of disease mechanisms and potential therapeutic strategies.

In academic and clinical research settings, TOM1 Gene Knockout Cell Lines provide a precise approach for examining gene function and assessing drug responses. Compared to conventional methods, these knockout lines mitigate background noise associated with genetic variability, ensuring clearer, more interpretable results. This specificity enhances the reliability of experimental outcomes, making them crucial for validating hypotheses in gene function studies.

The unique advantages of TOM1 Gene Knockout Cell Lines include their streamlined use in high-throughput screening assays, enabling efficient assessment of drug-target interactions and the evaluation of therapeutic candidates. Additionally, these resources come with detailed characterization, supporting reproducibility and promoting wider adoption in laboratories engaged in cellular and molecular biology research.

Our company prides itself on its extensive experience in providing cutting-edge biological research tools, underscored by a commitment to quality and innovation. With TOM1 Gene Knockout Cell Lines, researchers gain access to a robust resource that accelerates the discovery of novel insights within cellular systems, ultimately paving the way for significant advancements in clinical therapies and biopharmaceutical development.

Please note that all services are for research use only. Not intended for any clinical use.

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