Gene: TMX4
Official Full Name: thioredoxin related transmembrane protein 4provided by HGNC
Gene Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and C-terminal ASP/GLU-rich calcium binding domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The encoded protein has been shown to have reductase activity in vitro. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13132 | TMX4 Knockout cell line (HeLa) | Human | TMX4 | 1:3~1:6 | Negative | Online Inquiry |
KO13133 | TMX4 Knockout cell line (HCT 116) | Human | TMX4 | 1:2~1:4 | Negative | Online Inquiry |
KO13134 | TMX4 Knockout cell line (HEK293) | Human | TMX4 | 1:3~1:6 | Negative | Online Inquiry |
KO13135 | TMX4 Knockout cell line (A549) | Human | TMX4 | 1:3~1:4 | Negative | Online Inquiry |
TMX4 Gene Knockout Cell Lines are specialized cellular models that are engineered to lack expression of the TMX4 gene, a crucial component implicated in various biological processes, including oxidative stress response and cellular signaling. These knockout models serve as an essential tool for researchers investigating the functional role of TMX4 in disease mechanisms, notably in cancer and neurological disorders.
The primary function of the TMX4 Gene Knockout Cell Lines is to facilitate the study of gene function by providing a controlled environment where the TMX4 gene has been specifically disrupted. This gene editing is achieved through CRISPR/Cas9 technology, allowing for precise genomic modifications. By utilizing these knockout cells, researchers can explore the phenotypic consequences of TMX4 depletion, observe changes in cellular pathways, and assess the impacts on cell viability and proliferation.
Scientifically, the TMX4 Gene Knockout Cell Lines are invaluable in both basic and applied research settings. They enable the elucidation of the role of TMX4 in cellular stress responses, potentially leading to new therapeutic targets for conditions like hypertension and neurodegeneration. Additionally, these cell lines can be used in drug discovery processes to assess the efficacy of novel compounds on TMX4-related pathways.
What sets TMX4 Gene Knockout Cell Lines apart from alternative models is their genetic specificity and the rigorous validation of gene disruption. This provides assurance that any observed effects are directly attributable to the absence of the TMX4 gene, thus minimizing confounding variables that can arise from using less specific models. Furthermore, our cell lines are optimized for ease of use and reproducibility, allowing researchers to seamlessly integrate them into their workflows.
In conclusion, the TMX4 Gene Knockout Cell Lines represent a significant advancement for researchers seeking to understand the complexities of TMX4 in health and disease. Our company is committed to providing high-quality biological products developed through cutting-edge technologies and backed by expertise in molecular biology, ensuring our customers have the tools they need for groundbreaking research.
Please note that all services are for research use only. Not intended for any clinical use.
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