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TMX1 Knockout Cell Lines

Gene: TMX1

Official Full Name: thioredoxin related transmembrane protein 1provided by HGNC

Gene Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25785 TMX1 Knockout cell line (HeLa) Human TMX1 1:3~1:6 Negative Online Inquiry
KO25786 TMX1 Knockout cell line (HCT 116) Human TMX1 1:2~1:4 Negative Online Inquiry
KO25787 TMX1 Knockout cell line (HEK293) Human TMX1 1:3~1:6 Negative Online Inquiry
KO25788 TMX1 Knockout cell line (A549) Human TMX1 1:3~1:4 Negative Online Inquiry

Background

TMX1 Gene Knockout Cell Lines are state-of-the-art biological tools designed to facilitate the study of the TMX1 gene's role in cellular processes, disease models, and therapeutic interventions. These cell lines have been meticulously engineered through advanced CRISPR-Cas9 gene editing techniques, resulting in the complete disruption of the TMX1 gene across various cell types. By removing this gene, researchers can gain insights into its functional implications, providing a clearer picture of TMX1’s contributions to oxidative stress response, protein folding, and cellular apoptosis.

The fundamental mechanism of action for the TMX1 knockout cell lines involves the loss of TMX1 expression, which subsequently alters downstream signaling pathways that regulate redox states and cell metabolism. This enables scientists to explore the implications of TMX1 in conditions such as cancer, neurodegenerative disorders, and cardiovascular diseases. The ability to create disease models that simulate the absence of TMX1 paves the way for potential therapeutic discovery, biomarker identification, and the testing of pharmacological agents that could restore normal cellular function.

The scientific importance of these knockout cell lines cannot be overstated. They provide a unique platform for elucidating the mechanistic pathways associated with TMX1, making them invaluable for translational research and preclinical studies. Compared to traditional methods of gene knockdown, such as shRNA or siRNA, the TMX1 Gene Knockout Cell Lines offer permanent loss of function, allowing for more robust and replicable experimental outcomes.

What sets our product apart is not only its reliability and comprehensive characterization but also its adaptability across various research contexts. With a commitment to providing high-quality biological products, we ensure that our TMX1 Gene Knockout Cell Lines meet the demanding standards of today’s research and clinical environments. Our team, composed of experts proficient in molecular biology and genetics, is dedicated to supporting your research needs and driving innovations in the fields of biomedical and translational science.

Please note that all services are for research use only. Not intended for any clinical use.

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