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TMEM129 Knockout Cell Lines

Gene: TMEM129

Official Full Name: transmembrane protein 129, E3 ubiquitin ligaseprovided by HGNC

Gene Summary: Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23196 TMEM129 Knockout cell line (HeLa) Human TMEM129 1:3~1:6 Negative Online Inquiry
KO23197 TMEM129 Knockout cell line (HCT 116) Human TMEM129 1:2~1:4 Negative Online Inquiry
KO23198 TMEM129 Knockout cell line (HEK293) Human TMEM129 1:3~1:6 Negative Online Inquiry
KO23199 TMEM129 Knockout cell line (A549) Human TMEM129 1:3~1:4 Negative Online Inquiry

Background

TMEM129 gene knockout cell lines are genetically engineered cellular systems that lack the TMEM129 gene, which encodes for a transmembrane protein implicated in various cellular processes such as protein homeostasis and intracellular signaling pathways. By employing CRISPR-Cas9 or other gene-editing technologies, these knockout cell lines offer researchers a unique model for studying the biological functions associated with TMEM129, including its role in disease mechanisms such as cancer and neurodegenerative disorders.

The primary function of TMEM129 gene knockout cell lines lies in their ability to elucidate the molecular pathways influenced by TMEM129. The absence of this gene allows for the evaluation of the downstream effects on protein interaction networks, cellular proliferation, differentiation, and apoptosis. Researchers can utilize these cell lines to assess how the loss of TMEM129 impacts cellular responses to stimuli, drug treatments, or stress conditions, thereby providing insights into its functional relevance in health and disease.

These cell lines hold significant scientific importance and have valuable applications in both research and clinical settings. They can be utilized to develop targeted therapies by identifying compensatory mechanisms in TMEM129-deficient cells, explore biochemical pathways involved in drug resistance, and evaluate the impact of pharmacological interventions on cellular dynamics. Additionally, the ability to create TMEM129 knockout models accelerates the exploration of potential biomarkers for therapeutic efficacy.

What sets our TMEM129 gene knockout cell lines apart from alternatives lies in the precision of the gene-editing methodology employed, which ensures high specificity and reduced off-target effects. Our products are accompanied by extensive validation data, enabling researchers to base their experiments on a solid foundation of reliability and reproducibility.

The value of TMEM129 gene knockout cell lines is further amplified by their practical applications in drug discovery and precision medicine, offering researchers and clinicians a powerful tool to investigate the intricacies of TMEM129's role in various pathological states. By choosing our products, customers benefit not only from high-quality biological tools but also from our company's dedicated expertise in genetic engineering and cell line development, fostering an environment of scientific innovation and collaboration.

Please note that all services are for research use only. Not intended for any clinical use.

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