Gene: TMEM107
Official Full Name: transmembrane protein 107provided by HGNC
Gene Summary: This gene encodes a transmembrane protein and component of the primary cilia transition zone. The encoded protein regulates ciliogenesis and ciliary protein composition. Human fibroblasts expressing a mutant allele of this gene exhibit reduced numbers of cilia, altered cilia length, and impaired sonic hedgehog signaling. In human patients, different mutations in this gene cause different ciliopathies, including Meckel-Gruber syndrome and orofaciodigital syndrome. [provided by RefSeq, May 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24940 | TMEM107 Knockout cell line (HeLa) | Human | TMEM107 | 1:3~1:6 | Negative | Online Inquiry |
KO24941 | TMEM107 Knockout cell line (HCT 116) | Human | TMEM107 | 1:2~1:4 | Negative | Online Inquiry |
KO24942 | TMEM107 Knockout cell line (HEK293) | Human | TMEM107 | 1:3~1:6 | Negative | Online Inquiry |
KO24943 | TMEM107 Knockout cell line (A549) | Human | TMEM107 | 1:3~1:4 | Negative | Online Inquiry |
TMEM107 Gene Knockout Cell Lines are a powerful tool in molecular and cellular biology, specifically designed to study the function of the TMEM107 gene. This gene is implicated in various biological processes, including ciliary assembly and signaling pathways, making it a critical target for understanding cellular dynamics and disease mechanisms. These knockout cell lines have been engineered to disable the expression of the TMEM107 gene, providing researchers with a model to analyze the specific phenotypic and molecular consequences of its absence.
The primary function of the TMEM107 Gene Knockout Cell Lines lies in their ability to elucidate the role of the TMEM107 protein in key cellular events. By studying the altered signaling pathways and cellular behaviors in these knockout lines, researchers can gain insights into how disruptions in TMEM107 function contribute to various diseases, including ciliopathy and other genetic disorders. The mechanism of action involves employing CRISPR/Cas9 technology to induce a precise modification in the genome, ensuring a targeted and efficient gene knockout.
The scientific importance of these cell lines is underscored by their applications in both basic and applied research. In clinical settings, understanding the role of TMEM107 can lead to the identification of therapeutic targets for related conditions, thus enhancing disease treatment strategies. The experimental versatility these cell lines offer makes them invaluable for drug screening and validation processes.
Compared to alternative models, such as overexpression systems or wild-type cell lines, the TMEM107 Gene Knockout Cell Lines offer a more accurate and reliable means of studying gene function. By eliminating the TMEM107 gene, researchers can explore the resulting biological changes without interference from baseline gene activity, leading to clearer and more actionable data.
For researchers, clinicians, and pharmaceutical companies, the value of the TMEM107 Gene Knockout Cell Lines lies in their potential to drive innovation in therapeutic development and disease understanding. The insights gained from utilizing these lines can lead to significant breakthroughs in clinical practice and basic research.
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Please note that all services are for research use only. Not intended for any clinical use.
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