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TM4SF19 Knockout Cell Lines

Gene: TM4SF19

Official Full Name: transmembrane 4 L six family member 19provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30546 TM4SF19 Knockout cell line (HCT 116) Human TM4SF19 1:2~1:4 Negative Online Inquiry
KO30547 TM4SF19 Knockout cell line (A549) Human TM4SF19 1:3~1:4 Negative Online Inquiry

Background

TM4SF19 Gene Knockout Cell Lines are specialized cellular models designed to facilitate the functional study of the TM4SF19 gene, a member of the transmembrane 4 L SIX family of proteins, which plays a pivotal role in cell signaling, adhesion, and immune response modulation. These knockout cell lines have been genetically engineered through CRISPR-Cas9 technology to lack expression of the TM4SF19 gene, enabling researchers to investigate the biological implications of its loss in various cellular contexts.

The primary function of these knockout cell lines is to serve as invaluable tools for elucidating the roles of TM4SF19 in cellular pathways, disease mechanisms, and therapeutic responses. By examining the phenotypic and functional differences between the knockout and wild-type variants, researchers can gain insights into TM4SF19’s involvement in cancer progression, immune system regulation, and other critical biological processes. The use of these cell lines allows for reproducible and systematic exploration of gene function, aiding in the identification of potential therapeutic targets.

The scientific importance of TM4SF19 Gene Knockout Cell Lines extends to a variety of research and clinical applications, including drug discovery, biomarker identification, and understanding pathogenic mechanisms in diseases such as cancer and autoimmune disorders. They provide a robust framework for conducting high-throughput screening of compounds that could modulate TM4SF19-related pathways or for testing the efficacy of novel therapeutic strategies.

What sets TM4SF19 Gene Knockout Cell Lines apart from traditional cell models is their specificity and the precision with which they target the TM4SF19 gene. Unlike non-targeted approaches, these knockout lines offer a clear and unequivocal means to discern the functional consequences of TM4SF19 loss, thus significantly enhancing experimental accuracy. Researchers can also utilize these cell lines to validate findings in primary tissues or animal models.

For researchers and clinicians alike, the TM4SF19 Gene Knockout Cell Lines represent a vital resource in piecing together the complex puzzle of gene function and interaction in health and disease. By integrating these cell lines into their studies, scientists can push the boundaries of their research in understanding TM4SF19’s role.

Our company is dedicated to advancing scientific research through high-quality biological products, and our expertise in genetic model systems ensures that researchers have access to reliable and innovative tools to facilitate breakthroughs across various fields of study.

Please note that all services are for research use only. Not intended for any clinical use.

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