Gene: TLX1
Official Full Name: T cell leukemia homeobox 1provided by HGNC
Gene Summary: This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04909 | TLX1 Knockout cell line (HEK293) | Human | TLX1 | 1:3~1:6 | Negative | Online Inquiry |
TLX1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the TLX1 gene, also known as T-cell Lymphoma 1. This manipulation is achieved through advanced techniques such as CRISPR/Cas9 gene editing, which allows for precise modifications in the genome. As a result, these knockout cell lines serve as powerful tools for studying the biological functions of the TLX1 gene and its role in various cellular processes, particularly in lymphoid development and malignancies.
The key functions of TLX1 Gene Knockout Cell Lines lie in their ability to mimic the effects of TLX1 loss in a controlled laboratory environment. Researchers can utilize these cell lines to investigate the gene's contribution to T-cell differentiation, proliferation, and apoptosis, as well as its implications in the pathogenesis of T-cell leukemia. The study of these models provides critical insights into the molecular pathways involved in cancer and immune responses.
Scientifically, the significance of TLX1 Gene Knockout Cell Lines extends to both fundamental biology and translational research. They have applications in drug discovery, allowing scientists to test the efficacy of therapeutic agents targeting TLX1-related pathways, and in biomarker development to identify potential predictors of disease progression or treatment response.
Compared to traditional models, such as wild-type cell lines or animal models, TLX1 Gene Knockout Cell Lines offer advantages such as reduced inter-individual variability and the ability to perform high-throughput screening. Their specificity and relevance make them an invaluable resource for researchers and clinicians looking to delineate the role of TLX1 in health and disease.
Researchers and clinicians can greatly benefit from incorporating TLX1 Gene Knockout Cell Lines into their studies, as they provide a unique platform for dissecting complex biological processes and advancing therapeutic strategies. Our company is dedicated to delivering high-quality biological products, and we pride ourselves on our rigorous validation processes and deep expertise in gene editing technologies, ensuring that our offerings meet the highest standards for scientific research and application.
Please note that all services are for research use only. Not intended for any clinical use.
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