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THRA Knockout Cell Lines

Gene: THRA

Official Full Name: thyroid hormone receptor alphaprovided by HGNC

Gene Summary: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04639 THRA Knockout cell line (HeLa) Human THRA 1:3~1:6 Negative Online Inquiry
KO04640 THRA Knockout cell line (HCT 116) Human THRA 1:2~1:4 Negative Online Inquiry
KO04641 THRA Knockout cell line (HEK293) Human THRA 1:3~1:6 Negative Online Inquiry
KO04642 THRA Knockout cell line (A549) Human THRA 1:3~1:4 Negative Online Inquiry

Background

THRA Gene Knockout Cell Lines are genetically engineered cells specifically designed to lack the expression of the thyroid hormone receptor alpha (THRA) gene. This innovative product serves as a powerful tool for researchers aiming to investigate the critical roles of THRA in various biological processes, including metabolism, development, and gene regulation. By eliminating the THRA gene, these knockout cell lines provide an invaluable resource for studying downstream effects on metabolic pathways and understanding the receptor's implications in pathological conditions such as obesity, cardiovascular diseases, and cancer.

The primary mechanism of action of the THRA Gene Knockout Cell Lines lies in their ability to facilitate the dissection of THRA-mediated signaling pathways. By having a controlled environment where THRA is absent, researchers can precisely evaluate how THRA influences gene expression and cellular behaviors, allowing for robust data collection in functional assays. These cell lines are particularly advantageous for screening potential therapeutic targets and for validating the effects of compounds that modulate thyroid hormone signaling.

In scientific research and clinical applications, understanding THRA function is crucial. Dysregulation of thyroid hormone signaling has been implicated in metabolic disorders and developmental anomalies, making these knockout cell lines essential for elucidating these complex mechanisms. Researchers can leverage these tools to advance their understanding of disease models and develop effective therapeutic interventions.

What sets THRA Gene Knockout Cell Lines apart from alternative products on the market is not only their specificity but also the robustness of the background cell line utilized. Crafted using advanced gene editing techniques, these knockout lines ensure the reliability and repeatability needed for high-quality research. Compared to conventional methods like RNA interference or chemical inhibitors, knockout cell lines present a more permanent and stable solution for studying genetic functions, leading to clearer, more reproducible results.

For researchers and clinicians keen on exploring the nuances of thyroid signaling or developing new avenues of treatment, THRA Gene Knockout Cell Lines offer unparalleled value. Their capacity to facilitate comprehensive understanding and innovation in thyroid hormone research is unmatched.

Our company brings extensive expertise in the development of genetically modified cell lines, ensuring that our products are not only of the highest quality but also tailored to meet the specific needs of the scientific community. With a commitment to advancing research and clinical applications, we continue to innovate in the field of biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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