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TCN2 Knockout Cell Lines

Gene: TCN2

Official Full Name: transcobalamin 2provided by HGNC

Gene Summary: This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00632 TCN2 gRNA1-gRNA2 KO plasmid TCN2 $850
KO00832 TCN2 Knockout cell line(THP-1) Human TCN2 1:2-1:4 Negative Online Inquiry
KO13510 TCN2 Knockout cell line (HeLa) Human TCN2 1:3~1:6 Negative Online Inquiry
KO13511 TCN2 Knockout cell line (HCT 116) Human TCN2 1:2~1:4 Negative Online Inquiry
KO13512 TCN2 Knockout cell line (HEK293) Human TCN2 1:3~1:6 Negative Online Inquiry
KO13513 TCN2 Knockout cell line (A549) Human TCN2 1:3~1:4 Negative Online Inquiry

Background

TCN2 Gene Knockout Cell Lines are sophisticated biological tools designed for researchers seeking to unravel the functions of the transferrin-2 (TCN2) gene, which plays a pivotal role in iron homeostasis and cellular metabolism. These cell lines are engineered through the CRISPR-Cas9 gene-editing technology to achieve precise knockout of the TCN2 gene, allowing for comprehensive studies of the gene's biological implications in various cellular processes.

The primary function of TCN2 Gene Knockout Cell Lines lies in their ability to facilitate the analysis of the physiological consequences that arise from the absence of TCN2 expression. By providing a model system where researchers can observe changes in iron transport, reactive oxygen species production, and cellular signaling pathways, these knockout cell lines serve as critical tools for elucidating the gene's role in health and disease. Researchers can employ these lines to study how TCN2 deficiency may contribute to various pathologies, including anemia and neurodegenerative disorders.

The scientific importance of TCN2 knockout models extends into both basic research and clinical applications. They have become invaluable in pharmacological studies aimed at identifying potential drug targets for treating iron-related diseases and in investigating the implications of iron dysregulation on cellular physiology. This product stands out compared to alternative models due to its high specificity and efficiency of gene editing, coupled with a streamlined validation process ensuring consistent results.

Researchers and clinicians benefit significantly from using TCN2 Gene Knockout Cell Lines, as they provide a reliable system for exploring gene function in a controlled environment, thus accelerating the pace of scientific discovery. The capacity to generate detailed insights into the role of TCN2 empowers the development of targeted therapeutic interventions.

Our company has a strong commitment to advancing biological research, backed by a team of experts specializing in gene editing technologies and a portfolio of products designed to support innovative scientific inquiry. Trust in our offerings to provide you with high-quality, reproducible tools essential for your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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