Gene: TBX3
Official Full Name: T-box transcription factor 3provided by HGNC
Gene Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35103 | TBX3 Knockout cell line (HeLa) | Human | TBX3 | 1:3~1:6 | Negative | Online Inquiry |
KO35104 | TBX3 Knockout cell line (HCT 116) | Human | TBX3 | 1:2~1:4 | Negative | Online Inquiry |
KO35105 | TBX3 Knockout cell line (HEK293) | Human | TBX3 | 1:3~1:6 | Negative | Online Inquiry |
KO35106 | TBX3 Knockout cell line (A549) | Human | TBX3 | 1:3~1:4 | Negative | Online Inquiry |
TBX3 Gene Knockout Cell Lines are specialized cell culture systems in which the TBX3 gene has been inactivated to study the functional consequences of its absence. TBX3 is a member of the T-box family of transcription factors, crucial for various developmental processes, including limb formation and cardiac development. By using TBX3 gene knockout cell lines, researchers can investigate the cellular and molecular mechanisms underlying TBX3's role in gene expression regulation, cell differentiation, and developmental signaling pathways.
The functionality of these cell lines is rooted in their genetic modification, which allows for the analysis of phenotypic changes and aberrant signaling cascades typically driven by active TBX3. This manipulation not only facilitates the exploration of TBX3's regulatory networks but also aids in understanding its involvement in various pathological conditions, including cancer and congenital heart defects. The ability to observe these changes in a controlled environment makes TBX3 knockout cell lines invaluable for preclinical studies and therapeutic target identification.
The scientific importance of TBX3 gene knockout cell lines extends to both academic research and clinical applications. They serve as powerful tools in drug discovery, enabling the screening of compounds that can potentially modulate TBX3-related pathways, thus contributing to the development of targeted therapies. Furthermore, these cell lines provide insights into the genetic basis of diseases, helping clinicians to identify novel biomarkers and therapeutic interventions.
What truly sets our TBX3 Gene Knockout Cell Lines apart from alternative models is the precision of the gene-editing technology employed, ensuring a complete and reliable knockout. These cell lines are rigorously validated for consistent performance and reproducibility, making them a dependable resource for researchers. Their accessibility and ease of use position them as ideal candidates for high-throughput screening applications.
In conclusion, TBX3 Gene Knockout Cell Lines offer exceptional value to researchers and clinicians who aim to unravel the complexities of gene regulation and developmental biology. Our company has a proven track record in delivering high-quality biological products, underscored by a commitment to advancing scientific understanding and innovation in biosciences.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.