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TAX1BP1 Knockout Cell Lines

Gene: TAX1BP1

Official Full Name: Tax1 binding protein 1provided by HGNC

Gene Summary: This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06560 TAX1BP1 Knockout cell line (HeLa) Human TAX1BP1 1:3~1:6 Negative Online Inquiry
KO06561 TAX1BP1 Knockout cell line (HCT 116) Human TAX1BP1 1:2~1:4 Negative Online Inquiry
KO06562 TAX1BP1 Knockout cell line (HEK293) Human TAX1BP1 1:3~1:6 Negative Online Inquiry
KO06563 TAX1BP1 Knockout cell line (A549) Human TAX1BP1 1:3~1:4 Negative Online Inquiry

Background

TAX1BP1 Gene Knockout Cell Lines are engineered cellular models specifically designed for the study of TAX1-binding protein 1 (TAX1BP1) function and its role in various biological processes. Utilizing CRISPR-Cas9 gene-editing technology, these cell lines exhibit a complete loss of the TAX1BP1 protein, which plays a crucial role in intracellular signaling, immunity, and cell differentiation. By studying these knockout models, researchers can elucidate the mechanisms through which TAX1BP1 contributes to cellular responses and pathology, enhancing our understanding of diseases, particularly those involving immune dysregulation.

The key function of TAX1BP1 relates to its involvement in modulating autophagy and inflammation, serving as an important regulator in innate immune responses. The knockout of this gene disrupts these physiological processes, making the TAX1BP1 knockout models invaluable for dissecting the underlying pathways in disease mechanisms such as autoimmune disorders, cancer, and infectious diseases. Researchers can employ these models to screen for therapeutic compounds, identify potential drug targets, and understand gene-environment interactions in health and disease.

One of the primary advantages of our TAX1BP1 Gene Knockout Cell Lines compared to other models is their high specificity and efficiency due to the precision of CRISPR-Cas9 technology. This minimizes off-target effects and allows for the generation of clonal lines that faithfully recapitulate the gene knockout phenotype across multiple experiments. Additionally, our product is characterized by extensive supporting documentation and usage protocols, enabling user-friendly implementation in various experimental contexts.

For researchers and clinicians aiming to advance their knowledge in immunology, genetics, or therapeutic development, the TAX1BP1 Gene Knockout Cell Lines represent a pivotal tool. By providing unique insights into the biological roles of TAX1BP1, these models can significantly contribute to the discovery of novel therapeutic strategies and improve our understanding of disease pathophysiology.

Our company is dedicated to producing high-quality biological products that empower scientific discovery. With years of expertise in genetic engineering and a commitment to innovation, we strive to support researchers in their quest for knowledge, ensuring that our offerings meet the highest standards of scientific rigor and reliability.

Please note that all services are for research use only. Not intended for any clinical use.

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