Gene: TANC2
Official Full Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by HGNC
Gene Summary: Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Predicted to act upstream of or within in utero embryonic development. Located in dendritic spine. Implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28322 | TANC2 Knockout cell line (HeLa) | Human | TANC2 | 1:3~1:6 | Negative | Online Inquiry |
KO28323 | TANC2 Knockout cell line (HCT 116) | Human | TANC2 | 1:2~1:4 | Negative | Online Inquiry |
KO28324 | TANC2 Knockout cell line (HEK293) | Human | TANC2 | 1:3~1:6 | Negative | Online Inquiry |
KO28325 | TANC2 Knockout cell line (A549) | Human | TANC2 | 1:3~1:4 | Negative | Online Inquiry |
TANC2 Gene Knockout Cell Lines are genetically engineered cell lines designed to investigate the functional role of the TANC2 gene within various biological processes. Utilizing CRISPR/Cas9 technology, these cell lines have been specifically modified to disable the TANC2 gene, enabling researchers to explore its contribution to cellular signaling, neurodevelopment, and potential implications in neuropsychiatric disorders.
The primary mechanism behind the functionality of these knockout cell lines lies in the targeted deletion of the TANC2 gene, which eliminates the protein's expression and, consequently, allows for meticulous observation of downstream effects on cellular behavior, gene expression, and protein interactions. By studying these knockout lines, scientists can elucidate the multifaceted roles of TANC2 within synaptic development and stability, leading to a greater understanding of its relevance in conditions such as schizophrenia, autism spectrum disorder, and other neurological diseases.
In research and clinical settings, TANC2 Gene Knockout Cell Lines serve vital applications, including drug discovery, biomarker identification, and the elucidation of disease mechanisms. The use of these cell lines positions researchers to gain insights that could inform therapeutic approaches and precision medicine tailored to specific neurodevelopmental disorders.
The advantages of TANC2 Gene Knockout Cell Lines over alternative models include superior specificity and reproducibility, which are crucial for studies requiring accurate gene function assessment. Unlike traditional knockdown approaches, knockout cell lines provide a complete elimination of gene function, leading to more interpretable data and clearer insights into the biological impact of TANC2.
For researchers and clinicians, the value of TANC2 Gene Knockout Cell Lines lies in their potential to unlock novel research avenues and improve understanding of complex neurobiological functions. With their ability to bridge the gap between genetics and clinical implications, these cell lines are crucial tools for advancing neuroscience research.
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Please note that all services are for research use only. Not intended for any clinical use.
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