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TADA2A Knockout Cell Lines

Gene: TADA2A

Official Full Name: transcriptional adaptor 2Aprovided by HGNC

Gene Summary: Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35145 TADA2A Knockout cell line (HeLa) Human TADA2A 1:3~1:6 Negative Online Inquiry
KO35146 TADA2A Knockout cell line (HCT 116) Human TADA2A 1:2~1:4 Negative Online Inquiry
KO35147 TADA2A Knockout cell line (HEK293) Human TADA2A 1:3~1:6 Negative Online Inquiry

Background

TADA2A Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the TADA2A gene and its biological implications. These cell lines are created using advanced CRISPR-Cas9 technology, a revolutionary genome-editing tool that allows for precise and targeted gene modification. The knockout of the TADA2A gene serves as a powerful tool for researchers to investigate its role in various cellular processes, including transcriptional regulation, cell differentiation, and response to stress.

The primary mechanism of action of the TADA2A Gene Knockout Cell Lines lies in their ability to provide a platform for functional analysis of gene expression and protein interactions in a controlled environment. By observing the phenotypic changes resulting from TADA2A loss-of-function, researchers can glean insights into the gene's contributions to cellular function and pathology. This can be particularly valuable in studies related to cancer biology, neurodegenerative diseases, and developmental biology, where TADA2A may play a significant role.

The scientific importance of these knockout cell lines extends into both research and clinical applications. They can be utilized in drug discovery processes to identify potential therapeutic targets and validate the efficacy of new treatments. Moreover, their usage in functional genomics enables researchers to explore gene networks, cellular pathways, and potential biomarkers of diseases.

Compared to alternative methods of gene manipulation, such as overexpression or RNA interference, the TADA2A Gene Knockout Cell Lines offer distinct advantages. Knockout models provide a more comprehensive understanding of gene function by eliminating the gene, rather than merely reducing its expression. This results in a clearer interpretation of resultant phenotypes. Additionally, the reproducibility and scalability of these knockout cell lines facilitate high-throughput experimentation, making them ideal for extensive studies.

For researchers and clinicians seeking innovative solutions to advance their studies, the TADA2A Gene Knockout Cell Lines are invaluable tools that enhance our understanding of genetic contributions to health and disease. With a commitment to excellence in product development, our company leverages extensive expertise in molecular biology and genetic engineering to ensure that our offerings meet the highest standards of scientific integrity and utility.

Please note that all services are for research use only. Not intended for any clinical use.

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