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SYT7 Knockout Cell Lines

Gene: SYT7

Official Full Name: synaptotagmin 7provided by HGNC

Gene Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01022 SYT7 Knockout cell line (HEK293) Human SYT7 1:3~1:6 Negative Online Inquiry
KO33616 SYT7 Knockout cell line (HCT 116) Human SYT7 1:2~1:4 Negative Online Inquiry
KO33617 SYT7 Knockout cell line (A549) Human SYT7 1:3~1:4 Negative Online Inquiry

Background

SYT7 Gene Knockout Cell Lines are genetically engineered cell models that have had the SYT7 gene disrupted to facilitate the study of its biological functions in various physiological and pathological contexts. The SYT7 gene encodes a synaptotagmin protein implicated in neurotransmitter release and synaptic transmission, making these cell lines essential tools for neuroscience research.

The key functions of SYT7 Gene Knockout Cell Lines revolve around their ability to mimic the absence of the SYT7 protein, allowing researchers to investigate its role in synaptic signaling and neuronal communication. The knockout mechanism, achieved through techniques such as CRISPR/Cas9 or homologous recombination, ensures a precise deletion of the gene, leading to observable phenotypic changes that can be analyzed in vitro. Researchers can utilize these cell lines to assess alterations in calcium sensitivity, vesicle release dynamics, and overall synaptic activity.

The scientific importance of SYT7 Gene Knockout Cell Lines lies in their potential applications in both research and clinical settings. They can facilitate the investigation of neurological diseases, offering insights into mechanisms underlying disorders like epilepsy, autism spectrum disorders, and other synaptopathies. Their utilization in drug discovery and development also allows for the identification of novel therapeutic targets.

In comparison to alternative models, the unique selling points of SYT7 Gene Knockout Cell Lines include their specificity and reproducibility, which are crucial for obtaining reliable data. Additionally, these cell lines represent a precise genetic background, minimizing the confounding effects seen in heterogeneous cell populations commonly used in preliminary studies.

For researchers and clinicians aiming to deepen their understanding of synaptic function or develop new therapeutic strategies, SYT7 Gene Knockout Cell Lines represent an invaluable resource. Their ability to provide detailed insights into cellular mechanisms offers significant value, enhancing the potential for novel discoveries in the field of neuroscience.

Our company is committed to providing high-quality, innovative biological products that support cutting-edge research. We leverage advanced genetic engineering technologies and rigorous quality control to deliver reliable cell lines that meet the needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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