Gene: SYN3
Official Full Name: synapsin IIIprovided by HGNC
Gene Summary: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34276 | SYN3 Knockout cell line (HEK293) | Human | SYN3 | 1:3~1:6 | Negative | Online Inquiry |
SYN3 Gene Knockout Cell Lines represent a cutting-edge resource for researchers focused on gene function and genetic interactions. These cell lines have been engineered to specifically disrupt the SYN3 gene, a key player in neuronal signaling and synaptic functions. By using CRISPR-Cas9 technology, the SYN3 gene has been precisely knocked out, providing an invaluable tool to study the implications of this particular gene’s absence on cellular processes and organismal behavior.
The primary function of SYN3 Gene Knockout Cell Lines lies in their ability to facilitate investigations into the roles of synaptic proteins in neurobiology and disease models. Researchers can utilize these cell lines to explore fundamental biological questions surrounding neuronal development, signaling pathways, and synaptic plasticity. The mechanisms typically studied with these cell lines include altered neurotransmitter release, synapse formation, and cellular response to stimulation, providing a pathway for potential therapeutic interventions in neurodegenerative disorders.
SYN3 Gene Knockout Cell Lines stand out in the market due to their high specificity and reduced off-target effects compared to older methods such as traditional knockout strategies. This precision translates into more reliable data, vital for both basic and applied research endeavors. Their utility extends into pharmaceutical development and toxicology, offering a robust platform for testing drug efficacy and safety in neuronal contexts.
The value of SYN3 Gene Knockout Cell Lines extends to researchers and clinicians alike, enabling innovative studies that can lead to breakthroughs in understanding neuronal function and dysfunction. As a product of our dedication to advancing research tools, our company has a significant expertise in producing high-quality, genetically engineered cell lines tailored for specific investigative needs. With our commitment to supporting scientific discovery, we provide you with the reliable resources necessary to deepen your research and enhance clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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