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STAU2 Knockout Cell Lines

Gene: STAU2

Official Full Name: staufen double-stranded RNA binding protein 2provided by HGNC

Gene Summary: Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27889 STAU2 Knockout cell line (HeLa) Human STAU2 1:3~1:6 Negative Online Inquiry
KO27890 STAU2 Knockout cell line (HCT 116) Human STAU2 1:2~1:4 Negative Online Inquiry
KO27891 STAU2 Knockout cell line (HEK293) Human STAU2 1:3~1:6 Negative Online Inquiry
KO27892 STAU2 Knockout cell line (A549) Human STAU2 1:3~1:4 Negative Online Inquiry

Background

STAU2 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to silence the STAU2 gene, a critical regulator involved in post-transcriptional gene expression and RNA metabolism. These knockout cell lines facilitate the study of STAU2's biological functions by providing a controlled environment where the gene's contributions to cellular processes can be thoroughly investigated.

The primary function of the STAU2 gene is to encode a double-stranded RNA-binding protein that plays a pivotal role in mRNA stability, localization, and translational regulation. By eliminating the STAU2 gene, researchers can elucidate its inhibitory or promoting effects on specific mRNA targets, thereby enhancing the understanding of gene regulatory networks. The knockout approach also enables the exploration of potential compensatory mechanisms activated in response to the loss of STAU2, providing deeper insight into cellular adaptive responses.

The scientific importance of these cell lines is significant, as they can be utilized in various research applications, including cancer biology, cellular stress response studies, and developmental biology. In clinical settings, STAU2 Gene Knockout Cell Lines can aid in drug discovery and testing, particularly in identifying new therapeutic targets for diseases where STAU2 is implicated.

What sets our STAU2 Gene Knockout Cell Lines apart is their high specificity and the precision of the knockout achieved through advanced CRISPR/Cas9 technology. Unlike alternative genetic alteration methods, our product ensures that off-target effects are minimized, allowing for reliable and reproducible experimental outcomes. Furthermore, these cell lines are extensively validated for consistent performance, providing researchers with confidence in their experimental designs.

For researchers and clinicians, the value of STAU2 Gene Knockout Cell Lines lies in their capacity to advance the understanding of complex cellular mechanisms and enhance discoveries in gene regulation therapies. By utilizing these knockout models, researchers are empowered to dive deeper into cellular processes and potentially translate findings into innovative therapeutic strategies.

Our company, with years of expertise in cellular and molecular biology products, is dedicated to providing high-quality biological tools that support research advancements. With a commitment to innovation and excellence, we always strive to meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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