Gene: SSPN
Official Full Name: sarcospanprovided by HGNC
Gene Summary: This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34324 | SSPN Knockout cell line (A549) | Human | SSPN | 1:3~1:4 | Negative | Online Inquiry |
SSPN Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate precise investigations into the role of the SSPN gene (sarcolemma-associated protein) in various biological processes. These cell lines have been generated using advanced CRISPR/Cas9 technology to create knockout models, which lack the expression of the SSPN gene. This innovative tool is crucial for researchers aiming to elucidate the molecular mechanisms associated with SSPN, particularly its influence on muscle function, cell signaling pathways, and potential implications in muscular dystrophies.
The primary function of these knockout cell lines lies in their ability to offer a controlled environment for studying gene function and the resulting phenotypic changes that arise from the absence of the SSPN protein. By utilizing these cell lines, scientists can investigate the downstream effects on cellular integrity, survival, and signaling, thus enhancing our understanding of muscle biology and related disorders.
From a scientific research perspective, SSPN Gene Knockout Cell Lines provide invaluable insights into pathophysiological processes. They are particularly relevant in preclinical studies aimed at discovering therapeutic interventions for muscle-related diseases. Their application extends to pharmacological testing, where the effects of compounds on muscle performance can be accurately assessed without the confounding variables present in wild-type models.
What sets SSPN Gene Knockout Cell Lines apart from other genetic models is their specificity and the reliability afforded by the CRISPR/Cas9 knockdown methodology, which ensures a clean and efficient gene disruption. This specificity not only enhances the reproducibility of experimental results but also minimizes background noise, making these cell lines an optimal choice for high-throughput screening.
For researchers and clinicians focused on muscle science or related fields, these knockout cell lines are an essential asset, providing the necessary tools to drive innovation and discovery in understanding diseases at the genetic level. Our company has a longstanding commitment to advancing molecular biology research, offering high-quality genetic tools that empower scientists in their quest for knowledge and medical breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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