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SP100 Knockout Cell Lines

Gene: SP100

Official Full Name: SP100 nuclear antigenprovided by HGNC

Gene Summary: This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35269 SP100 Knockout cell line (HeLa) Human SP100 1:3~1:6 Negative Online Inquiry
KO35270 SP100 Knockout cell line (HCT 116) Human SP100 1:2~1:4 Negative Online Inquiry
KO35271 SP100 Knockout cell line (HEK293) Human SP100 1:3~1:6 Negative Online Inquiry
KO35272 SP100 Knockout cell line (A549) Human SP100 1:3~1:4 Negative Online Inquiry

Background

SP100 Gene Knockout Cell Lines are a premier tool designed for advanced functional genomics research and therapeutic development. These cell lines are engineered to contain targeted deletions of the SP100 gene, a key player in various cellular processes, including DNA repair, transcriptional regulation, and immune response modulation. By facilitating the study of gene function and elucidating the mechanisms behind disease pathology, SP100 knockout cell lines serve as a foundational resource for investigating the role of this gene in cellular behaviors and disease states.

The primary function of these knockout cell lines is to provide researchers with a versatile platform for analyzing the biological consequences of SP100 gene loss. The gene editing is achieved through precise techniques, such as CRISPR-Cas9, ensuring that the knockout phenotype is reliably established and maintained. Researchers can thus observe alterations in signaling pathways, cellular proliferation, apoptosis, and other critical processes that may result from the absence of SP100, advancing our understanding of its role in health and disease.

In clinical settings and research laboratories, SP100 knockout cell lines play an important role in drug discovery and development. They are particularly valuable for targeting diseases characterized by dysregulated immune responses, such as autoimmune disorders and cancers. Their application extends to gene function studies, phenotypic screening, and biomarker discovery, ultimately helping to uncover novel therapeutic targets.

What sets SP100 Gene Knockout Cell Lines apart from alternative products is their high specificity, reliability in knockout efficiency, and comprehensive supporting documentation that optimizes user experience. These cell lines are rigorously tested for quality, offering researchers confidence in their findings and promoting reproducibility in experimental designs.

For researchers, clinicians, and biopharmaceutical companies, the value of SP100 Gene Knockout Cell Lines lies in their ability to bridge the gap between basic research and clinical applications. By understanding gene function in greater detail, users can foster innovations in targeted therapies and enhance patient outcomes.

Our company specializes in the development of high-quality biological products, leveraging years of expertise in gene editing technologies to deliver tools that meet the rigorous demands of the scientific community. With a commitment to advancing research and therapeutic possibilities, we remain your trusted partner in genetic and cellular biology solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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