Gene: SNX1
Official Full Name: sorting nexin 1provided by HGNC
Gene Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35309 | SNX1 Knockout cell line (HeLa) | Human | SNX1 | 1:3~1:6 | Negative | Online Inquiry |
KO35310 | SNX1 Knockout cell line (HCT 116) | Human | SNX1 | 1:2~1:4 | Negative | Online Inquiry |
KO35311 | SNX1 Knockout cell line (HEK293) | Human | SNX1 | 1:3~1:6 | Negative | Online Inquiry |
KO35312 | SNX1 Knockout cell line (A549) | Human | SNX1 | 1:3~1:4 | Negative | Online Inquiry |
SNX1 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the SNX1 gene, which encodes for sorting nexins involved in cellular trafficking processes. By eliminating this gene, these cell lines provide a powerful tool for researchers to study the functional role of SNX1 in various biological processes, particularly those related to membrane trafficking and endosomal function. Characterized by altered cellular pathways, SNX1 knockout cells offer insights into the mechanisms underlying intracellular transport, protein sorting, and cellular signaling.
The primary function of SNX1 in normal cells is to mediate the sorting and trafficking of proteins to specific cellular compartments, thereby influencing membrane dynamics and endosomal integrity. In SNX1 knockout cell lines, researchers can observe the subsequent effects on cellular processes, including the degradation of membrane proteins and the regulation of receptor signaling pathways.
These cell lines hold significant scientific importance within both research and clinical settings. In research, they provide a model to study specific diseases linked to dysregulated endocytic pathways, such as cancer and neurodegenerative disorders. In clinical applications, understanding the downstream effects of SNX1 deficiency can pave the way for novel therapeutic strategies targeting pathways disrupted in disease states.
Compared to traditional models, SNX1 Gene Knockout Cell Lines offer distinct advantages, including the ability to precisely observe the role of SNX1 in a controlled environment, which often leads to more reproducible experimental results. Their use can significantly enhance the understanding of molecular mechanisms and lead to actionable insights.
This product is valuable for researchers and clinicians who require precise and reliable models to investigate the complexities of cell biology. With these knockout lines, users can accelerate their research efforts and develop innovative solutions to address pressing biological questions. Our company specializes in producing high-quality, genetically modified cell lines, ensuring researchers have access to the best tools for their studies.
Please note that all services are for research use only. Not intended for any clinical use.
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