Home / SNRPN Knockout Cell Lines

SNRPN Knockout Cell Lines

Gene: SNRPN

Official Full Name: small nuclear ribonucleoprotein polypeptide Nprovided by HGNC

Gene Summary: This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35328 SNRPN Knockout cell line (HeLa) Human SNRPN 1:3~1:6 Negative Online Inquiry
KO35329 SNRPN Knockout cell line (A549) Human SNRPN 1:3~1:4 Negative Online Inquiry

Background

SNRPN Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to create a loss-of-function model for studying the SNRPN gene, which is integral to the regulation of gene imprinting and critical for neural development. These cell lines serve as essential tools for examining the biological consequences of SNRPN deficiency, which has been associated with various neurological disorders, including Prader-Willi syndrome.

The primary function of the SNRPN Gene Knockout Cell Lines is to facilitate the investigation of gene expression alterations, cellular signaling pathways, and epigenetic modifications resulting from the absence of SNRPN. The knockout technique allows researchers to observe the phenotypic effects of gene silencing at both the cellular and molecular levels, thereby enabling a deeper understanding of the gene’s role in development and disease. The cell lines are commonly used in functional studies, drug screening, and gene therapy research, providing a reliable in vitro platform for biological experimentation.

The scientific importance of these cell lines is underscored by their utility in understanding complex genetic disorders. Researchers leverage SNRPN knockout models to elucidate pathogenic mechanisms and identify potential biomarkers that could lead to novel therapeutic approaches. Additionally, the ability to modify these cell lines further with CRISPR technology opens avenues for high-throughput screening and personalized medicine applications.

What sets our SNRPN Gene Knockout Cell Lines apart from alternatives in the market is their rigorously validated genetic modifications and characterized phenotypes, ensuring high reproducibility in experimental results. By providing comprehensive cell line documentation and user protocols, we enable scientists to achieve robust and reliable outcomes in their research.

For researchers and clinicians focused on genetic and neurodevelopmental studies, these knockout cell lines represent a vital resource. Their inclusion in experimental workflows can accelerate the discovery of insights that drive innovation in treatment strategies. At [Your Company Name], we pride ourselves on our expertise in genetic engineering and our commitment to supporting scientific discovery through high-quality biological products.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.