Gene: SMARCD3
Official Full Name: SWI/SNF related BAF chromatin remodeling complex subunit D3provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13950 | SMARCD3 Knockout cell line (HeLa) | Human | SMARCD3 | 1:3~1:6 | Negative | Online Inquiry |
KO13951 | SMARCD3 Knockout cell line (HCT 116) | Human | SMARCD3 | 1:2~1:4 | Negative | Online Inquiry |
KO13952 | SMARCD3 Knockout cell line (HEK293) | Human | SMARCD3 | 1:3~1:6 | Negative | Online Inquiry |
KO13953 | SMARCD3 Knockout cell line (A549) | Human | SMARCD3 | 1:3~1:4 | Negative | Online Inquiry |
SMARCD3 Gene Knockout Cell Lines are specialized cellular models designed to facilitate in-depth studies of the SWI/SNF chromatin remodeling complex’s role in gene regulation and cellular differentiation. These cell lines are engineered through CRISPR/Cas9 gene editing technology to achieve a specific knockout of the SMARCD3 gene, a crucial component associated with the remodeling of chromatin and transcriptional regulation. By eliminating the expression of SMARCD3, researchers can investigate the functional impact of chromatin structure changes on gene expression, cell cycle progression, and various cellular processes.
The mechanism underlying these knockout cell lines centers around the disruption of SMARCD3 function, which activates alternative pathways that compensate for the loss or reveals the essential roles this gene plays in specific contexts. This provides a valuable platform to explore the dysregulation of chromatin remodeling linked to cancer, developmental disorders, and other pathologies. Moreover, the SMARCD3 knockout model serves as a critical tool for testing therapeutic interventions aimed at restoring normal gene expression patterns.
In comparison to traditional cell lines, the SMARCD3 Gene Knockout Cell Lines offer unparalleled specificity and precision, enabling researchers to uncover nuanced biological interactions that may otherwise remain hidden. Their utility in both basic research and innovative therapeutic development enhances their appeal in academic and clinical settings. By employing these cell lines, researchers can drive forward the understanding of genomic regulation and establish novel targets for drug discovery.
Our company possesses a strong background in molecular biology and genetic engineering, ensuring the most reliable and rigorously validated products for our clients. With a commitment to advancing biological research, our SMARCD3 Gene Knockout Cell Lines stand out as an indispensable resource for scientists aiming to elucidate the complexities of chromatin remodeling and its implications in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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