Gene: SLC6A20
Official Full Name: solute carrier family 6 member 20provided by HGNC
Gene Summary: Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene belongs to the sodium:neurotransmitter symporter (SNF) family and functions as a proline transporter expressed in kidney and small intestine. Mutations in this gene are associated with Hyperglycinuria and Iminoglycinuria. [provided by RefSeq, Jul 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14102 | SLC6A20 Knockout cell line (HCT 116) | Human | SLC6A20 | 1:2~1:4 | Negative | Online Inquiry |
SLC6A20 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to eliminate the expression of the SLC6A20 gene, which is an important player in the transport of various amino acids across cellular membranes. These cell lines provide researchers with a powerful tool to investigate the functional implications of SLC6A20 in cellular metabolism, transport mechanisms, and metabolic disorders. By creating a knockout model, scientists can study the phenotypic consequences of lacking this transporter, including changes in growth, proliferation, and response to stressors.
The primary function of SLC6A20 involves facilitating the uptake of proline and other neutral amino acids, which plays a crucial role in maintaining cellular homeostasis and supporting protein synthesis. In using these knockout cell lines, researchers can elucidate the pathways coordinated by SLC6A20 and its involvement in conditions like cystinuria or certain types of cancer. The ability to observe how the lack of this gene affects cellular behavior fosters a better understanding of its role in health and disease, thereby contributing to the fields of molecular biology and therapeutic development.
What distinguishes SLC6A20 Gene Knockout Cell Lines from other genetic models is their specificity and versatility. While traditional models may present background noise from intact genes, these knockout lines allow for clearer insights into the consequences of gene termination. Furthermore, they may be used in high-throughput screening applications to identify therapeutic compounds that can modulate amino acid transport.
For researchers and clinicians, utilizing SLC6A20 Gene Knockout Cell Lines provides a significant advantage in understanding the genetic underpinnings of diseases, potentially leading to the development of targeted therapies and personalized medicine approaches. With the growing emphasis on precision medicine, this model enables a more nuanced analysis of treatment responses based on genetic profiles.
Our company is committed to advancing scientific inquiry with high-quality biological products and maintains a robust portfolio of genetically modified models, embodying our dedication to supporting cutting-edge research and improving clinical outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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