Gene: SLC38A5
Official Full Name: solute carrier family 38 member 5provided by HGNC
Gene Summary: The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02981 | SLC38A5 Knockout cell line (HeLa) | Human | SLC38A5 | 1:3~1:6 | Negative | Online Inquiry |
KO02982 | SLC38A5 Knockout cell line (HCT 116) | Human | SLC38A5 | 1:2~1:4 | Negative | Online Inquiry |
SLC38A5 Gene Knockout Cell Lines are specially engineered cellular models that possess a targeted disruption of the SLC38A5 gene, which encodes a solute carrier protein involved in the sodium-coupled transport of amino acids across cellular membranes. These cell lines are invaluable tools for investigating the physiological and pathological roles of the SLC38A5 gene in various biological processes such as nutrient transport, cellular signaling, and metabolic regulation. By creating a knockout model, researchers can elucidate the gene's specific functions and the resultant effects on amino acid homeostasis and overall cellular health.
The primary function of SLC38A5 knockout cell lines is to enable researchers to study the consequences of SLC38A5 deficiency on cellular phenotypes, signaling pathways, and interactions with other transporters. Mechanistically, the absence of SLC38A5 alters the transport dynamics of amino acids, which may lead to changes in cellular proliferation, apoptosis, and metabolic responses. This allows for comprehensive studies that provide insights into the gene's role in health and disease, including potential links to disorders like cancer, metabolic syndromes, or neurodegenerative diseases.
In scientific research and clinical applications, SLC38A5 knockout cell lines are instrumental for drug discovery and development, particularly in identifying new therapeutic targets and mechanisms of action. They offer an essential platform for assessing the biochemical and pharmacological impacts of compounds that affect amino acid transport and metabolism. Compared to traditional wild-type cell lines, these knockout models allow for more precise delineation of gene function, making them superior tools for experimental validation.
The unique value proposition of SLC38A5 knockout cell lines lies in their specificity and ability to provide clearer insights into gene function. Researchers and clinicians can leverage these models to accelerate the understanding of disease mechanisms and the development of novel therapeutic strategies. Furthermore, their ease of use and adaptability for high-throughput screening make them a preferred choice in many laboratories.
Our company prides itself on its expertise in genetic engineering and cellular biology, providing high-quality cellular models that meet the needs of contemporary research. We are committed to supporting the scientific community with innovative solutions that drive discovery and enhance understanding in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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