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SLC35B4 Knockout Cell Lines

Gene: SLC35B4

Official Full Name: solute carrier family 35 member B4provided by HGNC

Gene Summary: Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24494 SLC35B4 Knockout cell line (HeLa) Human SLC35B4 1:3~1:6 Negative Online Inquiry
KO24495 SLC35B4 Knockout cell line (HCT 116) Human SLC35B4 1:2~1:4 Negative Online Inquiry
KO24496 SLC35B4 Knockout cell line (HEK293) Human SLC35B4 1:3~1:6 Negative Online Inquiry
KO24497 SLC35B4 Knockout cell line (A549) Human SLC35B4 1:3~1:4 Negative Online Inquiry

Background

SLC35B4 gene knockout cell lines are sophisticated experimental tools designed to facilitate the study of the SLC35B4 gene's role in various biological processes. These cell lines are derived through targeted gene editing techniques, specifically CRISPR/Cas9 technology, which enables the precise disruption of the SLC35B4 gene, leading to the elimination of its protein product. This knockout approach allows researchers to explore the phenotypic consequences of disregarding SLC35B4, a gene implicated in nucleotide sugar transport and important in glycosylation pathways.

The key function of SLC35B4 involves its role in transporting UDP-sugars into the lumen of the endoplasmic reticulum and Golgi apparatus, essential for the proper synthesis of glycoproteins and glycolipids. By utilizing the SLC35B4 gene knockout cell lines, investigators can dissect the gene's involvement in cellular metabolism, signal transduction, and developmental processes, as well as its implications in various pathologies, including cancer and metabolic disorders.

Scientifically, SLC35B4 knockout models offer valuable insights that contribute to research in both basic and applied sciences, including drug development and therapeutic interventions. These models can reveal novel targets for pharmaceutical development, enhance understanding of disease mechanisms, and improve the interpretation of genetic studies.

What sets our SLC35B4 gene knockout cell lines apart from alternatives is their verified specificity and consistent performance across various experimental contexts. Unlike uncharacterized or inadequately validated cell lines, our knockout models are rigorously tested for genetic integrity and functional validation, ensuring that researchers are working with an accurate representation of the biological system of interest.

The utility of SLC35B4 gene knockout cell lines makes them an indispensable asset for researchers investigating molecular biology, genetics, and translational medicine. By providing a reliable platform for experimental manipulation, these cells enable the advancement of scientific knowledge and the development of innovative therapies.

Our company prides itself on its commitment to excellence in biological products, backed by years of expertise in genetic engineering and cell line development. We are dedicated to offering high-quality, tailored solutions that empower researchers and clinicians to achieve their scientific goals effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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