Gene: SLC25A29
Official Full Name: solute carrier family 25 member 29provided by HGNC
Gene Summary: This gene encodes a nuclear-encoded mitochondrial protein that is a member of the large family of solute carrier family 25 (SLC25) mitochondrial transporters. The members of this superfamily are involved in numerous metabolic pathways and cell functions. This gene product was previously reported to be a mitochondrial carnitine-acylcarnitine-like (CACL) translocase (PMID:128829710) or an ornithine transporter (designated ORNT3, PMID:19287344), however, a recent study characterized the main role of this protein as a mitochondrial transporter of basic amino acids, with a preference for arginine and lysine (PMID:24652292). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05430 | SLC25A29 Knockout cell line (HeLa) | Human | SLC25A29 | 1:3~1:6 | Negative | Online Inquiry |
KO05431 | SLC25A29 Knockout cell line (HCT 116) | Human | SLC25A29 | 1:2~1:4 | Negative | Online Inquiry |
KO05432 | SLC25A29 Knockout cell line (HEK293) | Human | SLC25A29 | 1:3~1:6 | Negative | Online Inquiry |
KO05433 | SLC25A29 Knockout cell line (A549) | Human | SLC25A29 | 1:3~1:4 | Negative | Online Inquiry |
SLC25A29 Gene Knockout Cell Lines are specifically engineered cellular models characterized by the targeted disruption of the SLC25A29 gene, which encodes a mitochondrial carrier protein involved in amino acid transport and metabolic regulation. This innovative cell line facilitates the study of the gene's role in cellular metabolism and disease pathology, offering insights into mitochondrial bioenergetics and cellular homeostasis.
The primary mechanism underlying the utility of SLC25A29 knockout cell lines involves their ability to eliminate the normal function of the SLC25A29 gene, thereby allowing researchers to observe the consequent physiological and biochemical changes. Through targeted gene editing technologies such as CRISPR-Cas9, these cell lines provide a powerful tool for elucidating the metabolic pathways influenced by this gene, enabling a deeper understanding of mitochondrial dysfunction and its implications in various disorders, including neurodegenerative diseases and metabolic syndromes.
The scientific importance of SLC25A29 gene knockout cell lines extends to their application in both basic research and clinical investigations, where they can be employed to screen potential drug candidates, study gene interactions, and model disease states. These cell lines offer a unique opportunity to identify novel therapeutic targets, thereby advancing personalized medicine and treatment strategies.
Compared to alternative models, such as wild-type cell lines or non-specific gene knockouts, SLC25A29 knockout cell lines provide specificity that can greatly increase the precision of experimental outcomes. They allow researchers to avoid off-target effects and focus on the specific contributions of the SLC25A29 gene to disease mechanisms.
For researchers and clinicians alike, SLC25A29 knockout cell lines represent an invaluable resource for understanding mitochondrial function and its link to health and disease. By harnessing these advanced cellular models, users can drive innovative research and accelerate the discovery of therapeutic interventions.
Our company is dedicated to advancing biological research through high-quality genetic models, ensuring that researchers have access to the best tools available to explore complex biological systems. Our expertise in genetic engineering and commitment to excellence makes us a trusted partner in the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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