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SIKE1 Knockout Cell Lines

Gene: SIKE1

Official Full Name: suppressor of IKBKE 1provided by HGNC

Gene Summary: SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05053 SIKE1 Knockout cell line (HeLa) Human SIKE1 1:3~1:6 Negative Online Inquiry
KO05054 SIKE1 Knockout cell line (HCT 116) Human SIKE1 1:2~1:4 Negative Online Inquiry
KO05055 SIKE1 Knockout cell line (HEK293) Human SIKE1 1:3~1:6 Negative Online Inquiry
KO05056 SIKE1 Knockout cell line (A549) Human SIKE1 1:3~1:4 Negative Online Inquiry

Background

SIKE1 Gene Knockout Cell Lines are specially engineered cells lacking the expression of the SIKE1 gene, which plays a critical role in various cellular processes, including signal transduction and apoptosis. The creation of these knockout cell lines involves advanced CRISPR-Cas9 gene editing technology, providing precise alterations to the genome. By studying these cell lines, researchers can delve into the functional implications of SIKE1 knockouts, particularly in the realms of cancer biology, immune response regulation, and cellular stress responses.

The key functions of SIKE1 have been linked to the modulation of key signaling pathways such as those influenced by inflammation and cellular growth. By knocking out the SIKE1 gene, scientists can observe the resultant phenotypic changes, shedding light on its role in tumor progression and metastasis. The high specificity and efficiency of CRISPR methodology ensure that these cell lines are robust models for investigating the cellular mechanisms underlying various pathologies in a controlled environment.

In research and clinical settings, SIKE1 Gene Knockout Cell Lines serve as valuable tools for drug discovery, aiding in the development of therapeutic strategies aimed at diseases driven by aberrant signaling pathways. Their application in translational research can enhance our understanding of the factors contributing to disease states, significantly impacting therapeutic approaches.

What sets our SIKE1 Gene Knockout Cell Lines apart is their high fidelity and reproducibility, allowing for consistent experimental outcomes. Unlike alternative models that may hold genetic variations affecting data interpretation, our cell lines ensure uniformity and reliability in research results.

This product is invaluable for researchers and clinicians aiming to unravel the complexities of cellular behavior and disease pathology, ultimately guiding them towards novel and effective treatments. As leaders in the field of genetic engineering, our company dedicates itself to providing high-quality, innovative biological tools that empower researchers and advance scientific knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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