Gene: SEPTIN5
Official Full Name: septin 5provided by HGNC
Gene Summary: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35987 | SEPTIN5 Knockout cell line (HeLa) | Human | SEPTIN5 | 1:3~1:6 | Negative | Online Inquiry |
KO35988 | SEPTIN5 Knockout cell line (HCT 116) | Human | SEPTIN5 | 1:2~1:4 | Negative | Online Inquiry |
KO35989 | SEPTIN5 Knockout cell line (HEK293) | Human | SEPTIN5 | 1:3~1:6 | Negative | Online Inquiry |
KO35990 | SEPTIN5 Knockout cell line (A549) | Human | SEPTIN5 | 1:3~1:4 | Negative | Online Inquiry |
SEPTIN5 Gene Knockout Cell Lines are engineered cellular models that specifically express a disrupted or non-functional SEPTIN5 gene. Septins are a family of GTP-binding proteins that play crucial roles in various cellular processes, including cytokinesis, cytoskeletal dynamics, and membrane trafficking. By creating knockout cell lines, researchers can investigate the role of SEPTIN5 in cellular mechanisms and pathology in a controlled environment, facilitating the study of its contribution to diseases such as cancer and neurodegenerative disorders.
The key mechanism by which these knockout cell lines operate is through the absence of SEPTIN5 protein, allowing scientists to delineate its functions in processes like cell division and migration. Understanding these mechanisms is vital, as SEPTIN5 has been implicated in cellular compartmentalization and can influence cytokine release and inflammation, underscoring its potential impact on both normal biology and disease.
The scientific importance of SEPTIN5 Gene Knockout Cell Lines extends to their application in research and clinical settings. They provide invaluable platforms for drug discovery, biomarker identification, and the study of genetic modifiers, enabling researchers to explore pathways that could lead to novel therapeutic strategies. By using these cell lines, scientists can elucidate molecular pathways in which SEPTIN5 is involved, making them essential tools in the quest to understand complex biological systems.
What sets SEPTIN5 Gene Knockout Cell Lines apart from alternative models is their specificity and versatility in experimental setups. They have been meticulously designed to ensure reproducibility and reliability, thus delivering consistency in experimental outcomes. Moreover, they are readily amenable to various assays, including high-throughput screening, providing significant time and cost efficiency for research initiatives.
Researchers and clinicians will find these knockout cell lines invaluable, as they provide the means to explore cellular functions related to SEPTIN5 in a way that traditional cell models cannot. Furthermore, our company boasts extensive experience in the development of cutting-edge biological products, ensuring that our offerings are not only of high quality but also supported by comprehensive technical expertise. This dedication to precision and advancement positions us as a trusted partner in your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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