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SENP8 Knockout Cell Lines

Gene: SENP8

Official Full Name: SUMO peptidase family member, NEDD8 specificprovided by HGNC

Gene Summary: This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02632 SENP8 Knockout cell line (HeLa) Human SENP8 1:3~1:6 Negative Online Inquiry
KO02633 SENP8 Knockout cell line (HCT 116) Human SENP8 1:2~1:4 Negative Online Inquiry
KO02634 SENP8 Knockout cell line (HEK293) Human SENP8 1:3~1:6 Negative Online Inquiry
KO02635 SENP8 Knockout cell line (A549) Human SENP8 1:3~1:4 Negative Online Inquiry

Background

SENP8 Gene Knockout Cell Lines are specialized cellular models designed for the study of gene function, specifically focusing on the role of the SENP8 gene in various biological processes. Utilizing advanced CRISPR-Cas9 gene editing technology, these cell lines have been engineered to disrupt the SENP8 gene, providing researchers with a powerful tool to examine its downstream effects on cellular pathways and phenotypes.

The primary function of SENP8 involves the regulation of SUMO (small ubiquitin-like modifier) modification, a post-translational modification that contributes significantly to protein interactions, stability, and localization. By knocking out the SENP8 gene, researchers can investigate how the absence of this specific SUMO protease impacts cellular processes such as proliferation, apoptosis, and stress responses, which are crucial for understanding diseases like cancer and neurodegeneration.

In both research and clinical settings, SENP8 Gene Knockout Cell Lines are invaluable. They serve as a model to identify potential therapeutic targets and unravel disease mechanisms by elucidating the role of SUMOylation. These insights are vital for the development of novel treatments and biomarker discovery, reflecting the increasing significance of SUMOylation in therapeutic interventions.

Compared to alternative models, SENP8 Gene Knockout Cell Lines offer a level of specificity and precision that enhances the reproducibility and reliability of experimental results. Their use eliminates unintended gene compensation effects that often complicate research involving partial perturbation of gene function, leading to clearer conclusions and robust data.

For researchers and clinicians, leveraging SENP8 Gene Knockout Cell Lines means accessing a streamlined approach to investigating complex biological questions and disease mechanisms. The product facilitates innovative research and lays the groundwork for advancements in targeted therapies and personalized medicine.

Our company prides itself on its expertise in cellular model systems and gene editing technologies. With a commitment to providing high-quality, scientifically validated products, we empower the research community to accelerate discoveries and improve outcomes in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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