Gene: SEMA4G
Official Full Name: semaphorin 4Gprovided by HGNC
Gene Summary: Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14222 | SEMA4G Knockout cell line (HeLa) | Human | SEMA4G | 1:3~1:6 | Negative | Online Inquiry |
KO14223 | SEMA4G Knockout cell line (HCT 116) | Human | SEMA4G | 1:2~1:4 | Negative | Online Inquiry |
KO14224 | SEMA4G Knockout cell line (HEK293) | Human | SEMA4G | 1:3~1:6 | Negative | Online Inquiry |
KO14225 | SEMA4G Knockout cell line (A549) | Human | SEMA4G | 1:3~1:4 | Negative | Online Inquiry |
SEMA4G Gene Knockout Cell Lines are engineered cellular models that have undergone targeted genetic modification to eliminate the expression of the SEMA4G gene. This gene encodes for a member of the semaphorin family, known to play significant roles in neuronal development and immune system regulation. By utilizing advanced CRISPR/Cas9 genome editing techniques, these cell lines allow researchers to study the precise biological functions and downstream effects of SEMA4G deficiency in various cellular contexts.
The primary function of SEMA4G Gene Knockout Cell Lines is to facilitate investigations into the mechanisms of cell signaling pathways modulated by semaphorin proteins, particularly in relation to neural and immune responses. Researchers can assess changes in cellular behavior, morphology, and gene expression patterns that arise from the absence of SEMA4G. This makes the cell lines invaluable tools for elucidating the role of SEMA4G in health and disease, including neurodegenerative disorders and cancer immunology.
In terms of scientific importance, these knockout cell lines provide a powerful platform for drug discovery and therapeutic development. Their ability to model specific genetic conditions allows for the exploration of potential interventions that may restore normal function or mitigate disease progression. Additionally, these cell lines can be employed in academic research settings to deepen our understanding of complex cellular interactions and signaling networks.
Compared to alternative models, such as wild-type cell lines or whole animal models, SEMA4G Gene Knockout Cell Lines offer heightened specificity and reproducibility in experimental outcomes. Their defined genetic background minimizes variability, leading to more reliable data that can streamline research efforts. Furthermore, they can be easily adapted for high-throughput screening applications, making them an ideal choice for both small and large-scale studies.
For researchers and clinicians focused on the intricacies of cellular signaling and its implications for disease, SEMA4G Gene Knockout Cell Lines represent a valuable addition to their research toolkit. By providing precise genetic modifications that directly target the SEMA4G gene, they significantly enhance the ability to study its implications in various biological and pathological contexts.
Our company specializes in developing high-quality genetic tools and cell lines, ensuring that our products are backed by rigorous scientific standards and a commitment to advancing research in the biological sciences. With our expertise, researchers can confidently explore new avenues of discovery using SEMA4G Gene Knockout Cell Lines as part of their investigative repertoire.
Please note that all services are for research use only. Not intended for any clinical use.
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