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SELENOT Knockout Cell Lines

Gene: SELENOT

Official Full Name: selenoprotein Tprovided by HGNC

Gene Summary: This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. Pseudogenes of this locus have been identified on chromosomes 9 and 5. [provided by RefSeq, Sep 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22241 SELENOT Knockout cell line (HeLa) Human SELENOT 1:3~1:6 Negative Online Inquiry
KO22242 SELENOT Knockout cell line (HCT 116) Human SELENOT 1:2~1:4 Negative Online Inquiry
KO22243 SELENOT Knockout cell line (HEK293) Human SELENOT 1:3~1:6 Negative Online Inquiry
KO22244 SELENOT Knockout cell line (A549) Human SELENOT 1:3~1:4 Negative Online Inquiry

Background

SELENOT Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the role of the SELENOT gene, which encodes for a selenoprotein involved in various biological processes including antioxidant defense and cellular signaling. By employing advanced CRISPR-Cas9 gene editing technology, these cell lines offer researchers a powerful tool to study not only the basic functions of SELENOT but also its implications in diseases such as cancer and neurodegenerative disorders.

The knockout mechanism disrupts the functionality of the SELENOT gene, allowing investigators to observe phenotypic changes that arise from the absence of this critical protein. The resultant cell lines serve as invaluable models to unravel the pathways in which SELENOT is involved, elucidating its role in cellular metabolism, apoptosis, and redox homeostasis. This process not only advances our understanding of fundamental biological mechanisms but also opens pathways to novel therapeutic strategies targeting SELENOT-associated dysfunctions.

In the landscape of research and clinical applications, SELENOT Gene Knockout Cell Lines stand out due to their ability to facilitate high-throughput screening and targeted approaches in drug discovery and development. Compared to traditional methodologies, these knockout models provide significant advantages, offering reproducibility, specificity, and efficiency in experimental outcomes.

For researchers and clinicians aiming to deepen their understanding of selenoprotein biology or develop innovative treatment modalities, the SELENOT Gene Knockout Cell Lines are an indispensable resource. With our company’s commitment to providing high-quality biological products backed by rigorous scientific rigor, we ensure that our offerings not only meet but exceed the expectations of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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