Gene: SCAMP4
Official Full Name: secretory carrier membrane protein 4provided by HGNC
Gene Summary: Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30869 | SCAMP4 Knockout cell line (HeLa) | Human | SCAMP4 | 1:3~1:6 | Negative | Online Inquiry |
KO30870 | SCAMP4 Knockout cell line (HCT 116) | Human | SCAMP4 | 1:2~1:4 | Negative | Online Inquiry |
KO30871 | SCAMP4 Knockout cell line (HEK293) | Human | SCAMP4 | 1:3~1:6 | Negative | Online Inquiry |
KO30872 | SCAMP4 Knockout cell line (A549) | Human | SCAMP4 | 1:3~1:4 | Negative | Online Inquiry |
SCAMP4 Gene Knockout Cell Lines represent a critical advancement in the study of cellular dynamics and protein function. These cell lines have been meticulously developed to facilitate the investigation of the SCAMP4 gene, known for its involvement in the processes of membrane trafficking and cellular signaling. By utilizing CRISPR-Cas9 technology, these knockout cell lines provide a robust model that allows researchers to achieve targeted gene disruption, enabling a deeper understanding of the physiological and pathological roles that SCAMP4 plays in various biological systems.
The mechanism behind the utility of SCAMP4 knockout cell lines lies in their capacity to elucidate the gene's specific contributions to cellular processes such as vesicle transport, exocytosis, and endocytosis. By studying these knockouts, researchers can observe the downstream effects of SCAMP4 deficiency on cell behavior, signaling pathways, and overall cell health. This makes them indispensable tools in both basic research and therapeutic development, particularly in areas such as cancer biology, neurobiology, and developmental biology.
The scientific importance of these cell lines cannot be overstated; they provide pivotal insights that can lead to novel therapeutic targets and inform drug development strategies. Compared to traditional methods, the advantages of using SCAMP4 knockout cell lines include their precision, reproducibility, and the ability to generate isogenic cells that help eliminate genetic variability as a confounding factor in experiments.
For researchers and clinicians, these knockout cell lines are invaluable in dissecting the complex roles of SCAMP4 in health and disease, facilitating advancements in personalized medicine and targeted therapies. The clear advantages offered by these models position them as superior alternatives to other genetic manipulation methods.
Our company specializes in providing high-quality biological products designed to accelerate research and innovation in life sciences. We are committed to ensuring that our offerings, like the SCAMP4 Gene Knockout Cell Lines, empower the scientific community to make significant strides in their understanding of molecular mechanisms and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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