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S100A14 Knockout Cell Lines

Gene: S100A14

Official Full Name: S100 calcium binding protein A14provided by HGNC

Gene Summary: This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14379 S100A14 Knockout cell line (HeLa) Human S100A14 1:3~1:6 Negative Online Inquiry
KO14380 S100A14 Knockout cell line (HCT 116) Human S100A14 1:2~1:4 Negative Online Inquiry

Background

S100A14 Gene Knockout Cell Lines represent a sophisticated tool for the investigation of cellular processes linked to the S100A14 gene, a member of the S100 protein family known for its role in calcium binding and intracellular signaling. These cell lines have been genetically engineered to disrupt the expression of S100A14, thereby providing a unique model system to study its functional implications in various biological contexts.

The key function of these knockout cell lines lies in their ability to facilitate the exploration of S100A14's involvement in processes such as cell proliferation, migration, and apoptosis. Through techniques like CRISPR-Cas9, the S100A14 gene is specifically targeted for deletion, allowing researchers to assess downstream effects on signaling pathways and cellular behavior with greater accuracy. This mechanism is crucial for understanding the gene's role in disease states, particularly in cancer and inflammatory responses.

In scientific research and clinical settings, S100A14 has been implicated in various disorders, making these knockout cell lines invaluable for elucidating its contribution to pathophysiology. Researchers can employ these systems to test hypotheses about S100A14’s function, assess potential therapeutic targets, and evaluate drug responses in a controlled manner.

Compared to traditional cell lines, which may retain S100A14 expression, these knockout models provide a clear, unambiguous background for direct analysis of S100A14-related functions. This specificity minimizes confounding variables, thereby enhancing the reliability of experimental outcomes. Furthermore, the ability to replicate results across various cell types enhances the translational potential of findings generated using these lines.

For researchers and clinicians, investing in S100A14 Gene Knockout Cell Lines opens new avenues for discovery and innovation. Their unique characteristics not only facilitate targeted studies but also encourage the development of novel therapeutic strategies, underscoring the importance of S100A14 in health and disease.

Our company specializes in providing high-quality biological products designed to support comprehensive research efforts. With a commitment to innovation and scientific rigor, we ensure that our offerings meet the needs of cutting-edge laboratories and contribute to advancements in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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