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RTN2 Knockout Cell Lines

Gene: RTN2

Official Full Name: reticulon 2provided by HGNC

Gene Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Reticulon proteins also play an important role in the replication of positive-strand RNA (ssRNA) viruses. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Aug 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35561 RTN2 Knockout cell line (HeLa) Human RTN2 1:3~1:6 Negative Online Inquiry
KO35562 RTN2 Knockout cell line (HCT 116) Human RTN2 1:2~1:4 Negative Online Inquiry
KO35563 RTN2 Knockout cell line (HEK293) Human RTN2 1:3~1:6 Negative Online Inquiry
KO35564 RTN2 Knockout cell line (A549) Human RTN2 1:3~1:4 Negative Online Inquiry

Background

RTN2 Gene Knockout Cell Lines are specialized cell lines engineered to lack the Reticulon 2 (RTN2) gene, a critical component involved in various cellular processes, including endoplasmic reticulum (ER) morphology, protein trafficking, and cellular stress responses. The knockout of the RTN2 gene allows researchers to explore its role in health and disease, particularly in neurodegenerative conditions and cancer.

These cell lines function by utilizing CRISPR-Cas9 genome-editing technology, ensuring precise deletion of the RTN2 gene, which results in observable phenotypic changes. Such alterations can serve as a vital indicator for dissecting cellular mechanisms related to the unfolded protein response, and thus, offer a model to study pathophysiology associated with ER stress.

The scientific importance of RTN2 Gene Knockout Cell Lines lies in their ability to facilitate investigations into the role of RTN2 in disease modeling and drug discovery. Their applications encompass fundamental research into cellular stress responses, neurological disorders, and cancer biology. By providing a clear comparative model, these cell lines enable researchers to dissect the impact of RTN2 loss on various cellular pathways and responses.

One significant advantage of our RTN2 Gene Knockout Cell Lines is their high reliability and reproducibility, ensuring consistent results across experiments. Compared to traditional knockout approaches, our product dramatically reduces off-target effects, offering enhanced specificity for research applications.

For researchers and clinicians, the value of RTN2 Gene Knockout Cell Lines is multifaceted; they provide robust tools for elucidating molecular mechanisms, advancing drug therapeutic strategies, and developing targeted interventions in diseases where RTN2 is implicated.

In conclusion, our commitment to advancing molecular biology tools is reflected in the rigorous development of these cell lines, underscoring our expertise and dedication to empowering scientific discovery in cutting-edge research and clinical settings.

Please note that all services are for research use only. Not intended for any clinical use.

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