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RSPO2 Knockout Cell Lines

Gene: RSPO2

Official Full Name: R-spondin 2provided by HGNC

Gene Summary: This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14413 RSPO2 Knockout cell line (HEK293) Human RSPO2 1:3~1:6 Negative Online Inquiry
KO39180 RSPO2 Knockout cell line (A549) Human RSPO2 1:3~1:4 Negative Online Inquiry

Background

RSPO2 Gene Knockout Cell Lines are engineered cell lines in which the RSPO2 gene, a critical regulator of the Wnt signaling pathway, has been systematically disrupted or "knocked out." This innovative biological product provides researchers with essential tools for exploring the intricate mechanisms of Wnt signaling and its implications in developmental biology, cancer, and regenerative medicine.

The primary function of these knockout cell lines is to facilitate the study of RSPO2's role in cellular processes, such as cell proliferation, differentiation, and apoptosis. By eliminating the RSPO2 gene, researchers can observe the downstream effects on Wnt signaling and better understand its contribution to various pathological conditions. This function is particularly crucial in investigating how the dysregulation of Wnt pathway components may lead to oncogenesis or developmental disorders, providing insights that could guide therapeutic strategies.

The scientific importance of RSPO2 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. In preclinical studies, these cell lines serve as a valuable model for testing potential cancer treatments or regenerative therapies. By understanding how the absence of RSPO2 influences cell behavior, scientists can design more targeted and effective interventions.

One of the key advantages of using our RSPO2 Gene Knockout Cell Lines is their specificity and reliability. Compared to traditional methods of gene silencing, such as shRNA or CRISPR/Cas9 techniques, our cell lines offer a permanent and stable knockout, ensuring reproducibility and consistency in experiments. Additionally, they help eliminate the off-target effects often associated with other gene-editing technologies, providing a clearer understanding of the RSPO2 gene function and its role within the Wnt signaling cascade.

This product is valuable to researchers and clinicians seeking to harness the power of gene knockout technology for groundbreaking discoveries. Our RSPO2 Gene Knockout Cell Lines empower users to investigate complex biological questions with confidence, potentially leading to significant advancements in therapeutic approaches for diseases linked to Wnt signaling dysregulation.

With a dedication to excellence, our company leverages cutting-edge biotechnological advancements and a robust understanding of genetics to deliver high-quality products that enhance research capabilities. Our commitment to scientific integrity and innovation positions us as a trusted partner in the life sciences community.

Please note that all services are for research use only. Not intended for any clinical use.

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