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RPS6KA4 Knockout Cell Lines

Gene: RPS6KA4

Official Full Name: ribosomal protein S6 kinase A4provided by HGNC

Gene Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10491 RPS6KA4 Knockout cell line (HeLa) Human RPS6KA4 1:3~1:6 Negative Online Inquiry
KO10492 RPS6KA4 Knockout cell line (HCT 116) Human RPS6KA4 1:2~1:4 Negative Online Inquiry
KO10493 RPS6KA4 Knockout cell line (HEK293) Human RPS6KA4 1:3~1:6 Negative Online Inquiry
KO10494 RPS6KA4 Knockout cell line (A549) Human RPS6KA4 1:3~1:4 Negative Online Inquiry

Background

RPS6KA4 Gene Knockout Cell Lines are specialized cellular models engineered to lack the RPS6KA4 (Ribosomal Protein S6 Kinase A4) gene, a crucial component involved in various cellular signaling pathways. These knockout cells serve as invaluable tools for investigating the fundamental roles of RPS6KA4 in physiological and pathological processes, particularly in cancer biology, metabolism, and neurological disorders.

The primary function of these RPS6KA4 gene knockout cell lines is to elucidate the gene's contribution to signal transduction pathways that regulate cell growth, proliferation, and differentiation. Mechanistically, RPS6KA4 is known to influence mTOR signaling, which is essential for protein synthesis and cellular metabolism. By using these knockout cell lines, researchers can closely analyze the downstream effects of the absence of RPS6KA4, thus providing insights into its role in malignancies and developmental processes.

In scientific research and clinical applications, these cell lines are invaluable for screening potential therapeutic compounds, understanding mechanisms of drug resistance, and elucidating novel targets for intervention against various diseases. They enable precise investigations into gene function, facilitating high-throughput studies and pathophysiological research that can lead to breakthroughs in treatment strategies.

The unique selling points of RPS6KA4 gene knockout cell lines include their high fidelity in mimicking in vivo conditions and their versatility for various experimental protocols, such as gene editing, signaling pathway analysis, and drug testing. Compared to conventional methods, these models reduce variability and enhance reproducibility, making them an ideal choice for researchers seeking reliable and accurate data.

In summary, RPS6KA4 Gene Knockout Cell Lines represent a cutting-edge resource for researchers and clinicians aiming to deepen their understanding of crucial biological mechanisms. Our commitment to excellence in the development of innovative biological products places us at the forefront of scientific advancement, offering high-quality resources that empower impactful research.

Please note that all services are for research use only. Not intended for any clinical use.

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